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Computational modeling of single-cell migration: the leading role of extracellular matrix fibers

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Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. / Schlueter, Daniela K.; Ramis-Conde, Ignacio; Chaplain, Mark A. J.
In: Biophysical Journal, Vol. 103, No. 6, 19.09.2012, p. 1141-1151.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Schlueter, DK, Ramis-Conde, I & Chaplain, MAJ 2012, 'Computational modeling of single-cell migration: the leading role of extracellular matrix fibers', Biophysical Journal, vol. 103, no. 6, pp. 1141-1151. https://doi.org/10.1016/j.bpj.2012.07.048

APA

Schlueter, D. K., Ramis-Conde, I., & Chaplain, M. A. J. (2012). Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. Biophysical Journal, 103(6), 1141-1151. https://doi.org/10.1016/j.bpj.2012.07.048

Vancouver

Schlueter DK, Ramis-Conde I, Chaplain MAJ. Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. Biophysical Journal. 2012 Sept 19;103(6):1141-1151. doi: 10.1016/j.bpj.2012.07.048

Author

Schlueter, Daniela K. ; Ramis-Conde, Ignacio ; Chaplain, Mark A. J. / Computational modeling of single-cell migration: the leading role of extracellular matrix fibers. In: Biophysical Journal. 2012 ; Vol. 103, No. 6. pp. 1141-1151.

Bibtex

@article{0f4cfbcffb6041b7923609b9ebe5ff81,
title = "Computational modeling of single-cell migration: the leading role of extracellular matrix fibers",
abstract = "Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.",
author = "Schlueter, {Daniela K.} and Ignacio Ramis-Conde and Chaplain, {Mark A. J.}",
note = " This is an Open Access article distributed under the terms of the Creative Commons-Attribution Noncommercial License (http://creativecommons. org/licenses/by-nc/2.0/), which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2012",
month = sep,
day = "19",
doi = "10.1016/j.bpj.2012.07.048",
language = "English",
volume = "103",
pages = "1141--1151",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Computational modeling of single-cell migration: the leading role of extracellular matrix fibers

AU - Schlueter, Daniela K.

AU - Ramis-Conde, Ignacio

AU - Chaplain, Mark A. J.

N1 - This is an Open Access article distributed under the terms of the Creative Commons-Attribution Noncommercial License (http://creativecommons. org/licenses/by-nc/2.0/), which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2012/9/19

Y1 - 2012/9/19

N2 - Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.

AB - Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.

U2 - 10.1016/j.bpj.2012.07.048

DO - 10.1016/j.bpj.2012.07.048

M3 - Journal article

VL - 103

SP - 1141

EP - 1151

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 6

ER -