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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Concentrations and patterns of organochlorines (OCs) in various fish species from the Indus River, Pakistan
T2 - a human health risk assessment
AU - Robinson, Timmer
AU - Ali, Usman
AU - Mahmood, Adeel
AU - Chaudhry, Muhammad Jamshed Iqbal
AU - Li, Jun
AU - Zhang, Gan
AU - Jones, Kevin C.
AU - Malik, Riffat Naseem
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Abstract The present study was conducted to reveal the concentrations and patterns of organochlorines [i.e., organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs)] in freshwater fish species collected from four ecologically important sites of the Indus River i.e., Taunsa (TAU), Rahim Yar Khan (RYK), Guddu (GUD) and Sukkur (SUK). In the fish muscle tissues, concentrations of 15 OCPs (∑15OCPs) and 29 PCBs (∑29PCBs) varied between 1.93–61.9 and 0.81–44.2 ng/g wet weight (ww), respectively. Overall, the rank order of OCs was DDTs > PCBs > hexachlorocyclohexanes (HCHs) > chlordanes (CHLs). The patterns of PCBs showed maximum contribution of tri-CBs (59%). Ratios of individual HCH and DDT analytes contributing to the summed values indicated both recent and past use of these chemicals in the region, depending upon fish species. To assess the associated health risks, carcinogenic and non-carcinogenic risks were calculated through hazard ratios (HRs). For carcinogenic risk, HR was > 1 at both 50th and 95th percentile concentrations, suggesting that the daily exposure to OCPs and PCBs yields a lifetime cancer risk of 1 in a million. HR for non-cancerous risk was < 1 at both the percentiles, signifying no adverse effect by OCs exposure in native population.
AB - Abstract The present study was conducted to reveal the concentrations and patterns of organochlorines [i.e., organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs)] in freshwater fish species collected from four ecologically important sites of the Indus River i.e., Taunsa (TAU), Rahim Yar Khan (RYK), Guddu (GUD) and Sukkur (SUK). In the fish muscle tissues, concentrations of 15 OCPs (∑15OCPs) and 29 PCBs (∑29PCBs) varied between 1.93–61.9 and 0.81–44.2 ng/g wet weight (ww), respectively. Overall, the rank order of OCs was DDTs > PCBs > hexachlorocyclohexanes (HCHs) > chlordanes (CHLs). The patterns of PCBs showed maximum contribution of tri-CBs (59%). Ratios of individual HCH and DDT analytes contributing to the summed values indicated both recent and past use of these chemicals in the region, depending upon fish species. To assess the associated health risks, carcinogenic and non-carcinogenic risks were calculated through hazard ratios (HRs). For carcinogenic risk, HR was > 1 at both 50th and 95th percentile concentrations, suggesting that the daily exposure to OCPs and PCBs yields a lifetime cancer risk of 1 in a million. HR for non-cancerous risk was < 1 at both the percentiles, signifying no adverse effect by OCs exposure in native population.
KW - Organochlorines
KW - Organochlorine pesticides
KW - Polychlorinated biphenyls
KW - Fish
KW - Indus River
KW - Pakistan
KW - Risk assessment
U2 - 10.1016/j.scitotenv.2015.10.002
DO - 10.1016/j.scitotenv.2015.10.002
M3 - Journal article
VL - 541
SP - 1232
EP - 1242
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
ER -