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Conservation of eukaryotic DNA repair mechanisms.

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Conservation of eukaryotic DNA repair mechanisms. / Taylor, Elaine M.; Lehmann, A.R.
In: International Journal of Radiation Biology, Vol. 74, No. 3, 1998, p. 277-286.

Research output: Contribution to Journal/Magazine › Literature review

Harvard

Taylor, EM & Lehmann, AR 1998, 'Conservation of eukaryotic DNA repair mechanisms.', International Journal of Radiation Biology, vol. 74, no. 3, pp. 277-286. https://doi.org/10.1080/095530098141429

APA

Taylor, E. M., & Lehmann, A. R. (1998). Conservation of eukaryotic DNA repair mechanisms. International Journal of Radiation Biology, 74(3), 277-286. https://doi.org/10.1080/095530098141429

Vancouver

Taylor EM, Lehmann AR. Conservation of eukaryotic DNA repair mechanisms. International Journal of Radiation Biology. 1998;74(3):277-286. doi: 10.1080/095530098141429

Author

Taylor, Elaine M. ; Lehmann, A.R. / Conservation of eukaryotic DNA repair mechanisms. In: International Journal of Radiation Biology. 1998 ; Vol. 74, No. 3. pp. 277-286.

Bibtex

@article{ac338bb7e2d447a9a160f77d05ff5bb9,
title = "Conservation of eukaryotic DNA repair mechanisms.",
abstract = "Purpose: To discuss the evolutionary conservation of different DNA repair processes. Summary: The proteins that carry out base excision repair show a varying degree of structural conservation, but a high level of functional complementation between species, as might be expected for a sequential pathway. In nucleotide excision repair there is a high degree of structural conservation, but few examples of functional complementation because the process involves multiprotein complexes. Repair by homologous recombination involves proteins that are highly conserved structurally. The process of repair of DNA breaks by non-homologous end-joining is conserved in eukaryotes, but the level of sequence identity of several of the proteins is fairly low and some components involved in man do not appear to have sequence homologues in yeast. Conclusions: All DNA repair processes are highly conserved. The degree of structural and functional conservation varies between the different processes.",
author = "Taylor, {Elaine M.} and A.R. Lehmann",
year = "1998",
doi = "10.1080/095530098141429",
language = "English",
volume = "74",
pages = "277--286",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Informa Healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Conservation of eukaryotic DNA repair mechanisms.

AU - Taylor, Elaine M.

AU - Lehmann, A.R.

PY - 1998

Y1 - 1998

N2 - Purpose: To discuss the evolutionary conservation of different DNA repair processes. Summary: The proteins that carry out base excision repair show a varying degree of structural conservation, but a high level of functional complementation between species, as might be expected for a sequential pathway. In nucleotide excision repair there is a high degree of structural conservation, but few examples of functional complementation because the process involves multiprotein complexes. Repair by homologous recombination involves proteins that are highly conserved structurally. The process of repair of DNA breaks by non-homologous end-joining is conserved in eukaryotes, but the level of sequence identity of several of the proteins is fairly low and some components involved in man do not appear to have sequence homologues in yeast. Conclusions: All DNA repair processes are highly conserved. The degree of structural and functional conservation varies between the different processes.

AB - Purpose: To discuss the evolutionary conservation of different DNA repair processes. Summary: The proteins that carry out base excision repair show a varying degree of structural conservation, but a high level of functional complementation between species, as might be expected for a sequential pathway. In nucleotide excision repair there is a high degree of structural conservation, but few examples of functional complementation because the process involves multiprotein complexes. Repair by homologous recombination involves proteins that are highly conserved structurally. The process of repair of DNA breaks by non-homologous end-joining is conserved in eukaryotes, but the level of sequence identity of several of the proteins is fairly low and some components involved in man do not appear to have sequence homologues in yeast. Conclusions: All DNA repair processes are highly conserved. The degree of structural and functional conservation varies between the different processes.

U2 - 10.1080/095530098141429

DO - 10.1080/095530098141429

M3 - Literature review

VL - 74

SP - 277

EP - 286

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 3

ER -