Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Conserved fever pathways across vertebrates
T2 - a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish
AU - Rakus, Krzysztof
AU - Ronsmans, Maygane
AU - Forlenza, Maria
AU - Boutier, Maxime
AU - Piazzon, M. Carla
AU - Jazowiecka-Rakus, Joanna
AU - Gatherer, Derek
AU - Athanasiadis, Alekos
AU - Farnir, Frédéric
AU - Davison, Andrew J.
AU - Boudinot, Pierre
AU - Michiels, Thomas
AU - Wiegertjes, Geert F.
AU - Vanderplasschen, Alain
PY - 2017/2/8
Y1 - 2017/2/8
N2 - Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.
AB - Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.
KW - behavioral fever
KW - fever
KW - herpesvirus
KW - cyprinid herpesvirus 3
KW - host-virus interactions
KW - pathogen-host-environment interplay
KW - immune evasion mechanisms
KW - innate immunity
KW - tumor necrosis factor α
KW - viral decoy receptor for cytokine
U2 - 10.1016/j.chom.2017.01.010
DO - 10.1016/j.chom.2017.01.010
M3 - Journal article
VL - 21
SP - 244
EP - 253
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 2
ER -