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Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish

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Conserved fever pathways across vertebrates : a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish. / Rakus, Krzysztof; Ronsmans, Maygane; Forlenza, Maria; Boutier, Maxime; Piazzon, M. Carla; Jazowiecka-Rakus, Joanna; Gatherer, Derek; Athanasiadis, Alekos; Farnir, Frédéric; Davison, Andrew J.; Boudinot, Pierre; Michiels, Thomas; Wiegertjes, Geert F.; Vanderplasschen, Alain.

In: Cell Host and Microbe, Vol. 21, No. 2, 08.02.2017, p. 244-253.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rakus, K, Ronsmans, M, Forlenza, M, Boutier, M, Piazzon, MC, Jazowiecka-Rakus, J, Gatherer, D, Athanasiadis, A, Farnir, F, Davison, AJ, Boudinot, P, Michiels, T, Wiegertjes, GF & Vanderplasschen, A 2017, 'Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish', Cell Host and Microbe, vol. 21, no. 2, pp. 244-253. https://doi.org/10.1016/j.chom.2017.01.010

APA

Rakus, K., Ronsmans, M., Forlenza, M., Boutier, M., Piazzon, M. C., Jazowiecka-Rakus, J., Gatherer, D., Athanasiadis, A., Farnir, F., Davison, A. J., Boudinot, P., Michiels, T., Wiegertjes, G. F., & Vanderplasschen, A. (2017). Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish. Cell Host and Microbe, 21(2), 244-253. https://doi.org/10.1016/j.chom.2017.01.010

Vancouver

Rakus K, Ronsmans M, Forlenza M, Boutier M, Piazzon MC, Jazowiecka-Rakus J et al. Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish. Cell Host and Microbe. 2017 Feb 8;21(2):244-253. https://doi.org/10.1016/j.chom.2017.01.010

Author

Rakus, Krzysztof ; Ronsmans, Maygane ; Forlenza, Maria ; Boutier, Maxime ; Piazzon, M. Carla ; Jazowiecka-Rakus, Joanna ; Gatherer, Derek ; Athanasiadis, Alekos ; Farnir, Frédéric ; Davison, Andrew J. ; Boudinot, Pierre ; Michiels, Thomas ; Wiegertjes, Geert F. ; Vanderplasschen, Alain. / Conserved fever pathways across vertebrates : a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish. In: Cell Host and Microbe. 2017 ; Vol. 21, No. 2. pp. 244-253.

Bibtex

@article{2974e868ebc741c7a8ac1fc671f029de,
title = "Conserved fever pathways across vertebrates: a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish",
abstract = "Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.",
keywords = "behavioral fever, fever, herpesvirus, cyprinid herpesvirus 3, host-virus interactions, pathogen-host-environment interplay, immune evasion mechanisms, innate immunity, tumor necrosis factor α, viral decoy receptor for cytokine",
author = "Krzysztof Rakus and Maygane Ronsmans and Maria Forlenza and Maxime Boutier and Piazzon, {M. Carla} and Joanna Jazowiecka-Rakus and Derek Gatherer and Alekos Athanasiadis and Fr{\'e}d{\'e}ric Farnir and Davison, {Andrew J.} and Pierre Boudinot and Thomas Michiels and Wiegertjes, {Geert F.} and Alain Vanderplasschen",
year = "2017",
month = feb,
day = "8",
doi = "10.1016/j.chom.2017.01.010",
language = "English",
volume = "21",
pages = "244--253",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Conserved fever pathways across vertebrates

T2 - a herpesvirus expressed decoy TNF-α receptor delays behavioral fever in fish

AU - Rakus, Krzysztof

AU - Ronsmans, Maygane

AU - Forlenza, Maria

AU - Boutier, Maxime

AU - Piazzon, M. Carla

AU - Jazowiecka-Rakus, Joanna

AU - Gatherer, Derek

AU - Athanasiadis, Alekos

AU - Farnir, Frédéric

AU - Davison, Andrew J.

AU - Boudinot, Pierre

AU - Michiels, Thomas

AU - Wiegertjes, Geert F.

AU - Vanderplasschen, Alain

PY - 2017/2/8

Y1 - 2017/2/8

N2 - Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.

AB - Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term “behavioral fever.” We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C–32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.

KW - behavioral fever

KW - fever

KW - herpesvirus

KW - cyprinid herpesvirus 3

KW - host-virus interactions

KW - pathogen-host-environment interplay

KW - immune evasion mechanisms

KW - innate immunity

KW - tumor necrosis factor α

KW - viral decoy receptor for cytokine

U2 - 10.1016/j.chom.2017.01.010

DO - 10.1016/j.chom.2017.01.010

M3 - Journal article

VL - 21

SP - 244

EP - 253

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 2

ER -