At the intersection of culture, ethnicity, gender, and religion, this paper offers insights into the lived experiences of Nigerian women by adopting Nkomo and Ngambi’s multilevel framework on African women’s leadership to understand their work-family experiences in the Nigerian banking sector. Employing data from interviews with eleven Northern women and ten Southern women who live in the following states: Kano, Kaduna; Akure, Lagos, Ibadan; and Abuja, the Federal Capital Territory, the findings confirm the existence of patriarchal systems at the macro (social), meso (organizational), and micro (individual) levels of social action that shape Nigerian women’s work-family experiences. Nevertheless, as tradition and modernity interact to provide a hybrid social space within which these women negotiate the different levels, they demonstrated the ability to redefine femininity and womanhood and reject constraints that confine them. The women from both regions resisted conformity to the patriarchal systematic ideologies and cultural processes that placed them in a disadvantaged position. Despite social and cultural criticisms that restrict women’s movement and career options, their agency was evident in their narratives.