Control of imaginal cell development by the escargot gene of Drosophila.

Biomedical and Life Sciences

Keywords

Mutation, Zinc finger structure, Gene expression, Imaginal disk, Diploidy, Larva, Adult animal, Postembryonic development, Drosophila, Drosophilidae, Diptera, Insecta, Arthropoda, Invertebrata

Research output: Contribution to Journal/Magazine › Journal article

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Control of imaginal cell development by the escargot gene of Drosophila. / Hayashi, S.; Hirose, S.; Metcalfe, T. et al.
In: Development, Vol. 118, No. 1, 1993, p. 105-115.

Research output: Contribution to Journal/Magazine › Journal article

Author

Hayashi, S. ; Hirose, S. ; Metcalfe, T. et al. / Control of imaginal cell development by the escargot gene of Drosophila. In: Development. 1993 ; Vol. 118, No. 1. pp. 105-115.

Bibtex

@article{65437e473fd34544ae7b4097f1660e34,

title = "Control of imaginal cell development by the escargot gene of Drosophila.",

abstract = "Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imaginal tissues is also found in third instar larvae. In esg mutant larvae, normally diploid abdominal histoblasts replicate their DNA without cell division and become similar in appearance to the polytene larval epidermal cells. A similar phenotype was also found in imaginal discs of larvae mutant for both esg and the Drosophila raf gene. These results suggest that one of the normal functions of esg may be the maintenance of diploidy in imaginal cells.",

keywords = "Mutation, Zinc finger structure, Gene expression, Imaginal disk, Diploidy, Larva, Adult animal, Postembryonic development, Drosophila, Drosophilidae, Diptera, Insecta, Arthropoda, Invertebrata",

author = "S. Hayashi and S. Hirose and T. Metcalfe and Shirras, {A. D.}",

year = "1993",

language = "English",

volume = "118",

pages = "105--115",

journal = "Development",

issn = "1477-9129",

publisher = "Company of Biologists Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Control of imaginal cell development by the escargot gene of Drosophila.

AU - Hayashi, S.

AU - Hirose, S.

AU - Metcalfe, T.

AU - Shirras, A. D.

PY - 1993

Y1 - 1993

N2 - Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imaginal tissues is also found in third instar larvae. In esg mutant larvae, normally diploid abdominal histoblasts replicate their DNA without cell division and become similar in appearance to the polytene larval epidermal cells. A similar phenotype was also found in imaginal discs of larvae mutant for both esg and the Drosophila raf gene. These results suggest that one of the normal functions of esg may be the maintenance of diploidy in imaginal cells.

AB - Mutations in the escargot (esg) locus, which codes for a zinc-finger-containing protein with similarity to the product of the snail gene, cause a variety of defects in adult structures such as loss of abdominal cuticle and malformation of the wings and legs. esg RNA is expressed in wing, haltere, leg and genital imaginal discs and in abdominal histoblast nests in the embryo. Expression in imaginal tissues is also found in third instar larvae. In esg mutant larvae, normally diploid abdominal histoblasts replicate their DNA without cell division and become similar in appearance to the polytene larval epidermal cells. A similar phenotype was also found in imaginal discs of larvae mutant for both esg and the Drosophila raf gene. These results suggest that one of the normal functions of esg may be the maintenance of diploidy in imaginal cells.

KW - Mutation

KW - Zinc finger structure

KW - Gene expression

KW - Imaginal disk

KW - Diploidy

KW - Larva

KW - Adult animal

KW - Postembryonic development

KW - Drosophila

KW - Drosophilidae

KW - Diptera

KW - Insecta

KW - Arthropoda

KW - Invertebrata

M3 - Journal article

VL - 118

SP - 105

EP - 115

JO - Development

JF - Development

SN - 1477-9129

IS - 1

ER -

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