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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Controlled Sr(ii) ion release from
AU - Fırlak Demirkan, Melike
AU - Öztürk, Dilek
AU - Çifçibaşı, Zeynep Sude
AU - Ertan, Fatma
AU - Hardy, John George
AU - Nurşeval Oyunlu, Aslı
AU - Darıcı, Hakan
PY - 2024/1/31
Y1 - 2024/1/31
N2 - The development of electrochemical stimuli-responsive drug delivery systems is of both academic and industrial interest due to the ease with which it is possible to trigger payload release, providing drug delivery in a controllable manner. Herein, the preparation of forming hydrogels including electroactive polypyrrole nanoparticles (PPy-NPs) where Sr ions are electrochemically loaded for electrically triggered release of Sr ions is reported. The hydrogels were characterized by a variety of techniques including Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), cyclic voltammetry (CV), The cytocompatibility towards human mesenchymal stem cells (MSCs) and fibroblasts were also studied. The Sr ion loaded PEC-ALD/CS/PPy-NPs hydrogel showed no significant cytotoxicity towards human mesenchymal stem cells (MSCs) and fibroblasts. Sr ions were electrochemically loaded and released from the electroactive hydrogels, and the application of an electrical stimulus enhanced the release of Sr ions from gels by 2-4 fold relative to the passive release control experiment. The antibacterial activity of Sr ions against and was demonstrated . Although these prototypical examples of Sr loaded electroactive gels don't release sufficient Sr ions to show antibacterial activity against and , we believe future iterations with optimised physical properties of the gels will be capable of doing so. [Abstract copyright: This journal is © The Royal Society of Chemistry.]
AB - The development of electrochemical stimuli-responsive drug delivery systems is of both academic and industrial interest due to the ease with which it is possible to trigger payload release, providing drug delivery in a controllable manner. Herein, the preparation of forming hydrogels including electroactive polypyrrole nanoparticles (PPy-NPs) where Sr ions are electrochemically loaded for electrically triggered release of Sr ions is reported. The hydrogels were characterized by a variety of techniques including Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), cyclic voltammetry (CV), The cytocompatibility towards human mesenchymal stem cells (MSCs) and fibroblasts were also studied. The Sr ion loaded PEC-ALD/CS/PPy-NPs hydrogel showed no significant cytotoxicity towards human mesenchymal stem cells (MSCs) and fibroblasts. Sr ions were electrochemically loaded and released from the electroactive hydrogels, and the application of an electrical stimulus enhanced the release of Sr ions from gels by 2-4 fold relative to the passive release control experiment. The antibacterial activity of Sr ions against and was demonstrated . Although these prototypical examples of Sr loaded electroactive gels don't release sufficient Sr ions to show antibacterial activity against and , we believe future iterations with optimised physical properties of the gels will be capable of doing so. [Abstract copyright: This journal is © The Royal Society of Chemistry.]
U2 - 10.1039/d3ra07061a
DO - 10.1039/d3ra07061a
M3 - Journal article
C2 - 38304567
VL - 14
SP - 4324
EP - 4334
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 7
ER -