Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
}
TY - GEN
T1 - Correlation Between Spontaneous Phenotypic Changes in Pseudomonas Strains with Changes in the Structure of Catabolic Plasmids
T2 - Experiences with TOL Plasmids
AU - Williams, Peter A.
AU - Cane, Patricia A.
AU - Jeenes, David J.
AU - Pickup, Roger W.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - It is part of the traditional lore of microbiology departments, handed down by word of mouth but largely unrecorded in the literature, that bacteria, isolated from the environment for their ability to perform particularly interesting metabolic functions, often show an infuriating instability. The usual version of the story is that a strain, originally obtained by selective enrichment on some esoteric compound as sole carbon source, could no longer grow on that compound after sitting on a slope for several months. In other versions, instability was a regular occurrence and part of a routine laboratory practice would be to reisolate the original strain from a selective medium. Occasionally a promising sequence of publications on a particularly interesting strain became abruptly terminated due to the failure to resuscitate it from its premature functional demise.
AB - It is part of the traditional lore of microbiology departments, handed down by word of mouth but largely unrecorded in the literature, that bacteria, isolated from the environment for their ability to perform particularly interesting metabolic functions, often show an infuriating instability. The usual version of the story is that a strain, originally obtained by selective enrichment on some esoteric compound as sole carbon source, could no longer grow on that compound after sitting on a slope for several months. In other versions, instability was a regular occurrence and part of a routine laboratory practice would be to reisolate the original strain from a selective medium. Occasionally a promising sequence of publications on a particularly interesting strain became abruptly terminated due to the failure to resuscitate it from its premature functional demise.
U2 - 10.1007/978-1-4684-4460-5_28
DO - 10.1007/978-1-4684-4460-5_28
M3 - Conference contribution/Paper
AN - SCOPUS:0020881098
SN - 0306412446
SN - 9780306412448
T3 - Basic Life Sciences
SP - 519
EP - 552
BT - Basic Biology of New Developments in Biotechnology
A2 - Hollaender, A.
PB - Plenum Press
ER -