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Cuticle preparations from Necator americanus and their immunogenicity in the infected host.

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Cuticle preparations from Necator americanus and their immunogenicity in the infected host. / Pritchard, David Idris; McKean, Paul G.; Rogan, Michael Thomas.

In: Molecular and Biochemical Parasitology, Vol. 28, No. 3, 04.1988, p. 275-283.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Pritchard, DI, McKean, PG & Rogan, MT 1988, 'Cuticle preparations from Necator americanus and their immunogenicity in the infected host.', Molecular and Biochemical Parasitology, vol. 28, no. 3, pp. 275-283. https://doi.org/10.1016/0166-6851(88)90012-6

APA

Vancouver

Author

Pritchard, David Idris ; McKean, Paul G. ; Rogan, Michael Thomas. / Cuticle preparations from Necator americanus and their immunogenicity in the infected host. In: Molecular and Biochemical Parasitology. 1988 ; Vol. 28, No. 3. pp. 275-283.

Bibtex

@article{3dbc399e2b81481bb2adadbc9dd7f76f,
title = "Cuticle preparations from Necator americanus and their immunogenicity in the infected host.",
abstract = "Cuticle samples have been prepared from the human parasitic nematode Necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol. It would appear that N. americanus, like many other nematodes, relies on relatively small collagenous proteins, linked by disulphide bonds, to maintain the integrity of its cuticle. These molecules are normally hidden from the immune system during the course of infection but are potentially immunogenic. It is suggested that waves of antibodies, firstly with specificity against superficial cuticular epitopes followed by antibodies against deeper lying, structural elements, should be induced during vaccination to effectively destroy the nematode at the cuticular level.",
author = "Pritchard, {David Idris} and McKean, {Paul G.} and Rogan, {Michael Thomas}",
year = "1988",
month = apr,
doi = "10.1016/0166-6851(88)90012-6",
language = "English",
volume = "28",
pages = "275--283",
journal = "Molecular and Biochemical Parasitology",
issn = "0166-6851",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Cuticle preparations from Necator americanus and their immunogenicity in the infected host.

AU - Pritchard, David Idris

AU - McKean, Paul G.

AU - Rogan, Michael Thomas

PY - 1988/4

Y1 - 1988/4

N2 - Cuticle samples have been prepared from the human parasitic nematode Necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol. It would appear that N. americanus, like many other nematodes, relies on relatively small collagenous proteins, linked by disulphide bonds, to maintain the integrity of its cuticle. These molecules are normally hidden from the immune system during the course of infection but are potentially immunogenic. It is suggested that waves of antibodies, firstly with specificity against superficial cuticular epitopes followed by antibodies against deeper lying, structural elements, should be induced during vaccination to effectively destroy the nematode at the cuticular level.

AB - Cuticle samples have been prepared from the human parasitic nematode Necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol. It would appear that N. americanus, like many other nematodes, relies on relatively small collagenous proteins, linked by disulphide bonds, to maintain the integrity of its cuticle. These molecules are normally hidden from the immune system during the course of infection but are potentially immunogenic. It is suggested that waves of antibodies, firstly with specificity against superficial cuticular epitopes followed by antibodies against deeper lying, structural elements, should be induced during vaccination to effectively destroy the nematode at the cuticular level.

U2 - 10.1016/0166-6851(88)90012-6

DO - 10.1016/0166-6851(88)90012-6

M3 - Journal article

VL - 28

SP - 275

EP - 283

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

SN - 0166-6851

IS - 3

ER -