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Cuticular collagens – a concealed target for immune attack in hookworms.

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Cuticular collagens – a concealed target for immune attack in hookworms. / Pritchard, David Idris; McKean, Paul G.; Rogan, Michael Thomas.

In: Parasitology Today, Vol. 4, No. 9, 09.1988, p. 239-241.

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Pritchard, David Idris ; McKean, Paul G. ; Rogan, Michael Thomas. / Cuticular collagens – a concealed target for immune attack in hookworms. In: Parasitology Today. 1988 ; Vol. 4, No. 9. pp. 239-241.

Bibtex

@article{583741dd7b444d27b47159ea62e1ffbd,
title = "Cuticular collagens – a concealed target for immune attack in hookworms.",
abstract = "Protective immunity is a primary goal in the development of ontiparositic vaccines. Often however, parasite immunologists are faced with chronic infections that apparently do not induce a protective immune response. But although epitopes presented by some parasites may fail to induce protective immunity, there may be other antigens normally concealed from the host that, if revealed, could stimulate the required response. Indeed, there is evidence that some drugs — such as praziquantel — can act in this way, by revealing hidden parasite antigens that then induce the protective response. Vaccination with {\textquoteleft}concealed{\textquoteright} antigens is already being developed to control ectoporasitic ticks (see Parasitology Today 4,196–198). This article suggests a similar approach for hookworm vaccines, by which a {\textquoteleft}first-wave{\textquoteright} attack would be stimulated by surface antigens, followed by a {\textquoteleft}second-wave{\textquoteright} attack directed against the underlying cuticular collagens o f the parasite.",
author = "Pritchard, {David Idris} and McKean, {Paul G.} and Rogan, {Michael Thomas}",
year = "1988",
month = sep,
doi = "10.1016/0169-4758(88)90137-8",
language = "English",
volume = "4",
pages = "239--241",
journal = "Parasitology Today",
issn = "0169-4758",
publisher = "Elsevier BV",
number = "9",

}

RIS

TY - JOUR

T1 - Cuticular collagens – a concealed target for immune attack in hookworms.

AU - Pritchard, David Idris

AU - McKean, Paul G.

AU - Rogan, Michael Thomas

PY - 1988/9

Y1 - 1988/9

N2 - Protective immunity is a primary goal in the development of ontiparositic vaccines. Often however, parasite immunologists are faced with chronic infections that apparently do not induce a protective immune response. But although epitopes presented by some parasites may fail to induce protective immunity, there may be other antigens normally concealed from the host that, if revealed, could stimulate the required response. Indeed, there is evidence that some drugs — such as praziquantel — can act in this way, by revealing hidden parasite antigens that then induce the protective response. Vaccination with ‘concealed’ antigens is already being developed to control ectoporasitic ticks (see Parasitology Today 4,196–198). This article suggests a similar approach for hookworm vaccines, by which a ‘first-wave’ attack would be stimulated by surface antigens, followed by a ‘second-wave’ attack directed against the underlying cuticular collagens o f the parasite.

AB - Protective immunity is a primary goal in the development of ontiparositic vaccines. Often however, parasite immunologists are faced with chronic infections that apparently do not induce a protective immune response. But although epitopes presented by some parasites may fail to induce protective immunity, there may be other antigens normally concealed from the host that, if revealed, could stimulate the required response. Indeed, there is evidence that some drugs — such as praziquantel — can act in this way, by revealing hidden parasite antigens that then induce the protective response. Vaccination with ‘concealed’ antigens is already being developed to control ectoporasitic ticks (see Parasitology Today 4,196–198). This article suggests a similar approach for hookworm vaccines, by which a ‘first-wave’ attack would be stimulated by surface antigens, followed by a ‘second-wave’ attack directed against the underlying cuticular collagens o f the parasite.

U2 - 10.1016/0169-4758(88)90137-8

DO - 10.1016/0169-4758(88)90137-8

M3 - Journal article

VL - 4

SP - 239

EP - 241

JO - Parasitology Today

JF - Parasitology Today

SN - 0169-4758

IS - 9

ER -