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CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations

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CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations. / Wassenaar, Catherine A.; Ye, Yuanqing; Cai, Qiuyin et al.
In: Carcinogenesis, Vol. 36, No. 1, 01.2015, p. 99-103.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Wassenaar, CA, Ye, Y, Cai, Q, Aldrich, MC, Knight, J, Spitz, MR, Wu, X, Blot, WJ & Tyndale, RF 2015, 'CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations', Carcinogenesis, vol. 36, no. 1, pp. 99-103. https://doi.org/10.1093/carcin/bgu235

APA

Wassenaar, C. A., Ye, Y., Cai, Q., Aldrich, M. C., Knight, J., Spitz, M. R., Wu, X., Blot, W. J., & Tyndale, R. F. (2015). CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations. Carcinogenesis, 36(1), 99-103. https://doi.org/10.1093/carcin/bgu235

Vancouver

Wassenaar CA, Ye Y, Cai Q, Aldrich MC, Knight J, Spitz MR et al. CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations. Carcinogenesis. 2015 Jan;36(1):99-103. Epub 2014 Nov 21. doi: 10.1093/carcin/bgu235

Author

Wassenaar, Catherine A. ; Ye, Yuanqing ; Cai, Qiuyin et al. / CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers : findings from two independent populations. In: Carcinogenesis. 2015 ; Vol. 36, No. 1. pp. 99-103.

Bibtex

@article{c09d51897f854b70b02fb5ac02863f93,
title = "CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers: findings from two independent populations",
abstract = "We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African American ever-smokers, drawn from two independent lung cancer case-control studies, were genotyped for reduced activity CYP2A6 alleles and grouped by predicted metabolic activity. Lung cancer risk in the Southern Community Cohort Study (n = 494) was lower among CYP2A6 reduced versus normal metabolizers, as estimated by multivariate conditional logistic regression [odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.26-0.73] and by unconditional logistic regression (OR = 0.62; 95% CI = 0.41-0.94). The association was replicated in an independent study from MD Anderson Cancer Center (n = 407) (OR = 0.64; 95% CI = 0.42-0.98), and pooling the studies yielded an OR of 0.64 (95% CI = 0.48-0.86). Exploratory analyses revealed a significant interaction between CYP2A6 genotype and sex on the risk for lung cancer (Southern Community Cohort Study: P = 0.04; MD Anderson: P = 0.03; Pooled studies: P = 0.002) with a CYP2A6 effect in men only. These findings support a contribution of genetic variation in CYP2A6 to lung cancer risk among African American smokers, particularly men, whereby CYP2A6 genotypes associated with reduced metabolic activity confer a lower risk of developing lung cancer.",
keywords = "Adenocarcinoma, African Americans, Carcinoma, Squamous Cell, Case-Control Studies, Cytochrome P-450 CYP2A6, European Continental Ancestry Group, Female, Follow-Up Studies, Genotype, Humans, Lung Neoplasms, Male, Middle Aged, Polymorphism, Genetic, Prognosis, Prospective Studies, Risk Factors, Smoking",
author = "Wassenaar, {Catherine A.} and Yuanqing Ye and Qiuyin Cai and Aldrich, {Melinda C.} and Joanne Knight and Spitz, {Margaret R.} and Xifeng Wu and Blot, {William J.} and Tyndale, {Rachel F.}",
note = "{\textcopyright} The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
year = "2015",
month = jan,
doi = "10.1093/carcin/bgu235",
language = "English",
volume = "36",
pages = "99--103",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers

T2 - findings from two independent populations

AU - Wassenaar, Catherine A.

AU - Ye, Yuanqing

AU - Cai, Qiuyin

AU - Aldrich, Melinda C.

AU - Knight, Joanne

AU - Spitz, Margaret R.

AU - Wu, Xifeng

AU - Blot, William J.

AU - Tyndale, Rachel F.

N1 - © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PY - 2015/1

Y1 - 2015/1

N2 - We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African American ever-smokers, drawn from two independent lung cancer case-control studies, were genotyped for reduced activity CYP2A6 alleles and grouped by predicted metabolic activity. Lung cancer risk in the Southern Community Cohort Study (n = 494) was lower among CYP2A6 reduced versus normal metabolizers, as estimated by multivariate conditional logistic regression [odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.26-0.73] and by unconditional logistic regression (OR = 0.62; 95% CI = 0.41-0.94). The association was replicated in an independent study from MD Anderson Cancer Center (n = 407) (OR = 0.64; 95% CI = 0.42-0.98), and pooling the studies yielded an OR of 0.64 (95% CI = 0.48-0.86). Exploratory analyses revealed a significant interaction between CYP2A6 genotype and sex on the risk for lung cancer (Southern Community Cohort Study: P = 0.04; MD Anderson: P = 0.03; Pooled studies: P = 0.002) with a CYP2A6 effect in men only. These findings support a contribution of genetic variation in CYP2A6 to lung cancer risk among African American smokers, particularly men, whereby CYP2A6 genotypes associated with reduced metabolic activity confer a lower risk of developing lung cancer.

AB - We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African American ever-smokers, drawn from two independent lung cancer case-control studies, were genotyped for reduced activity CYP2A6 alleles and grouped by predicted metabolic activity. Lung cancer risk in the Southern Community Cohort Study (n = 494) was lower among CYP2A6 reduced versus normal metabolizers, as estimated by multivariate conditional logistic regression [odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.26-0.73] and by unconditional logistic regression (OR = 0.62; 95% CI = 0.41-0.94). The association was replicated in an independent study from MD Anderson Cancer Center (n = 407) (OR = 0.64; 95% CI = 0.42-0.98), and pooling the studies yielded an OR of 0.64 (95% CI = 0.48-0.86). Exploratory analyses revealed a significant interaction between CYP2A6 genotype and sex on the risk for lung cancer (Southern Community Cohort Study: P = 0.04; MD Anderson: P = 0.03; Pooled studies: P = 0.002) with a CYP2A6 effect in men only. These findings support a contribution of genetic variation in CYP2A6 to lung cancer risk among African American smokers, particularly men, whereby CYP2A6 genotypes associated with reduced metabolic activity confer a lower risk of developing lung cancer.

KW - Adenocarcinoma

KW - African Americans

KW - Carcinoma, Squamous Cell

KW - Case-Control Studies

KW - Cytochrome P-450 CYP2A6

KW - European Continental Ancestry Group

KW - Female

KW - Follow-Up Studies

KW - Genotype

KW - Humans

KW - Lung Neoplasms

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Prognosis

KW - Prospective Studies

KW - Risk Factors

KW - Smoking

U2 - 10.1093/carcin/bgu235

DO - 10.1093/carcin/bgu235

M3 - Journal article

C2 - 25416559

VL - 36

SP - 99

EP - 103

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 1

ER -