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Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus

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Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus. / Hehnly, Christine; Ssentongo, Paddy; Bebell, Lisa M. et al.
In: International Journal of Infectious Diseases, Vol. 118, 31.05.2022, p. 24-33.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hehnly, C, Ssentongo, P, Bebell, LM, Burgoine, K, Bazira, J, Fronterre, C, Kumbakumba, E, Mulondo, R, Mbabazi-Kabachelor, E, Morton, SU, Ngonzi, J, Ochora, M, Olupot-Olupot, P, Onen, J, Roberts, DJ, Sheldon, K, Sinnar, SA, Smith, J, Ssenyonga, P, Paulson, JN, Meier, FA, Ericson, JE, Broach, JR & Schiff, SJ 2022, 'Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus', International Journal of Infectious Diseases, vol. 118, pp. 24-33. https://doi.org/10.1016/j.ijid.2022.02.005

APA

Hehnly, C., Ssentongo, P., Bebell, L. M., Burgoine, K., Bazira, J., Fronterre, C., Kumbakumba, E., Mulondo, R., Mbabazi-Kabachelor, E., Morton, S. U., Ngonzi, J., Ochora, M., Olupot-Olupot, P., Onen, J., Roberts, D. J., Sheldon, K., Sinnar, S. A., Smith, J., Ssenyonga, P., ... Schiff, S. J. (2022). Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus. International Journal of Infectious Diseases, 118, 24-33. https://doi.org/10.1016/j.ijid.2022.02.005

Vancouver

Hehnly C, Ssentongo P, Bebell LM, Burgoine K, Bazira J, Fronterre C et al. Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus. International Journal of Infectious Diseases. 2022 May 31;118:24-33. Epub 2022 Feb 8. doi: 10.1016/j.ijid.2022.02.005

Author

Hehnly, Christine ; Ssentongo, Paddy ; Bebell, Lisa M. et al. / Cytomegalovirus Infections in Ugandan Infants : Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus. In: International Journal of Infectious Diseases. 2022 ; Vol. 118. pp. 24-33.

Bibtex

@article{33ceeba718ab4fb78e09ec84a2481b5f,
title = "Cytomegalovirus Infections in Ugandan Infants: Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus",
abstract = "Objective To estimate the prevalence of cytomegalovirus (CMV) infections in newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. Design and Methods Three populations: (1) newborn-mother pairs, (2) neonates with sepsis, and (3) infants (≤ 3 months) with non-postinfectious (NPIH) or postinfectious (PIH) hydrocephalus, were evaluated for CMV infection at three medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV. Results The overall CMV prevalence in 2498 samples in duplicate across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis there was a 2% CMV prevalence. Maternal HIV seropositivity (aOR, 25.20; 95% CI, 4.43-134.26; p= 0.0001), residence in Eastern Uganda (aOR, 11.06; 95% CI, 2.30-76.18; p=0.003), maternal age < 25 years (aOR, 4.54; 95% CI, 1.40-19.29; p=0.02), and increasing neonatal age (aOR, 1.08 for each day older; 95% CI, 1.00-1.16; p= 0.05), were associated risk factors for CMV in neonates with clinical sepsis. We found a two-fold higher maternal vaginal shedding in Eastern (45%) vs Western (22%) Uganda during parturition (n=22/49 vs. 11/50, Fisher's exact test, p=0.02). In infants with PIH, the prevalence in blood was 24% and in infants with NPIH it was 20%. CMV was present in the CSF of 13% of infants with PIH compared to 0.5% of infants with NPIH (n=26/205 vs. 1/194, p<0.0001). Conclusion Our findings highlight that congenital and postnatal CMV prevalence is substantial in this African setting and the long-term consequences are uncharacterized.",
keywords = "Infectious Diseases, Microbiology (medical), General Medicine",
author = "Christine Hehnly and Paddy Ssentongo and Bebell, {Lisa M.} and Kathy Burgoine and Joel Bazira and Claudio Fronterre and Elias Kumbakumba and Ronald Mulondo and Edith Mbabazi-Kabachelor and Morton, {Sarah U.} and Joseph Ngonzi and Moses Ochora and Peter Olupot-Olupot and Justin Onen and Roberts, {Drucilla J.} and Kathryn Sheldon and Sinnar, {Shamim A.} and Jasmine Smith and Peter Ssenyonga and Paulson, {Joseph N.} and Meier, {Frederick A.} and Ericson, {Jessica E.} and Broach, {James R.} and Schiff, {Steven J.}",
year = "2022",
month = may,
day = "31",
doi = "10.1016/j.ijid.2022.02.005",
language = "English",
volume = "118",
pages = "24--33",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Cytomegalovirus Infections in Ugandan Infants

T2 - Newborn-Mother Pairs, Neonates with Sepsis, and Infants with Hydrocephalus

AU - Hehnly, Christine

AU - Ssentongo, Paddy

AU - Bebell, Lisa M.

AU - Burgoine, Kathy

AU - Bazira, Joel

AU - Fronterre, Claudio

AU - Kumbakumba, Elias

AU - Mulondo, Ronald

AU - Mbabazi-Kabachelor, Edith

AU - Morton, Sarah U.

AU - Ngonzi, Joseph

AU - Ochora, Moses

AU - Olupot-Olupot, Peter

AU - Onen, Justin

AU - Roberts, Drucilla J.

AU - Sheldon, Kathryn

AU - Sinnar, Shamim A.

AU - Smith, Jasmine

AU - Ssenyonga, Peter

AU - Paulson, Joseph N.

AU - Meier, Frederick A.

AU - Ericson, Jessica E.

AU - Broach, James R.

AU - Schiff, Steven J.

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Objective To estimate the prevalence of cytomegalovirus (CMV) infections in newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. Design and Methods Three populations: (1) newborn-mother pairs, (2) neonates with sepsis, and (3) infants (≤ 3 months) with non-postinfectious (NPIH) or postinfectious (PIH) hydrocephalus, were evaluated for CMV infection at three medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV. Results The overall CMV prevalence in 2498 samples in duplicate across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis there was a 2% CMV prevalence. Maternal HIV seropositivity (aOR, 25.20; 95% CI, 4.43-134.26; p= 0.0001), residence in Eastern Uganda (aOR, 11.06; 95% CI, 2.30-76.18; p=0.003), maternal age < 25 years (aOR, 4.54; 95% CI, 1.40-19.29; p=0.02), and increasing neonatal age (aOR, 1.08 for each day older; 95% CI, 1.00-1.16; p= 0.05), were associated risk factors for CMV in neonates with clinical sepsis. We found a two-fold higher maternal vaginal shedding in Eastern (45%) vs Western (22%) Uganda during parturition (n=22/49 vs. 11/50, Fisher's exact test, p=0.02). In infants with PIH, the prevalence in blood was 24% and in infants with NPIH it was 20%. CMV was present in the CSF of 13% of infants with PIH compared to 0.5% of infants with NPIH (n=26/205 vs. 1/194, p<0.0001). Conclusion Our findings highlight that congenital and postnatal CMV prevalence is substantial in this African setting and the long-term consequences are uncharacterized.

AB - Objective To estimate the prevalence of cytomegalovirus (CMV) infections in newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. Design and Methods Three populations: (1) newborn-mother pairs, (2) neonates with sepsis, and (3) infants (≤ 3 months) with non-postinfectious (NPIH) or postinfectious (PIH) hydrocephalus, were evaluated for CMV infection at three medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV. Results The overall CMV prevalence in 2498 samples in duplicate across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis there was a 2% CMV prevalence. Maternal HIV seropositivity (aOR, 25.20; 95% CI, 4.43-134.26; p= 0.0001), residence in Eastern Uganda (aOR, 11.06; 95% CI, 2.30-76.18; p=0.003), maternal age < 25 years (aOR, 4.54; 95% CI, 1.40-19.29; p=0.02), and increasing neonatal age (aOR, 1.08 for each day older; 95% CI, 1.00-1.16; p= 0.05), were associated risk factors for CMV in neonates with clinical sepsis. We found a two-fold higher maternal vaginal shedding in Eastern (45%) vs Western (22%) Uganda during parturition (n=22/49 vs. 11/50, Fisher's exact test, p=0.02). In infants with PIH, the prevalence in blood was 24% and in infants with NPIH it was 20%. CMV was present in the CSF of 13% of infants with PIH compared to 0.5% of infants with NPIH (n=26/205 vs. 1/194, p<0.0001). Conclusion Our findings highlight that congenital and postnatal CMV prevalence is substantial in this African setting and the long-term consequences are uncharacterized.

KW - Infectious Diseases

KW - Microbiology (medical)

KW - General Medicine

U2 - 10.1016/j.ijid.2022.02.005

DO - 10.1016/j.ijid.2022.02.005

M3 - Journal article

VL - 118

SP - 24

EP - 33

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -