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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils
AU - Rabe, Rebecca
AU - Hempel, Ute
AU - Martocq, Laurine
AU - Keppler, Julia K.
AU - Aveyard, Jenny
AU - Douglas, Timothy
PY - 2020/8/3
Y1 - 2020/8/3
N2 - To improve integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g. fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI’s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote human bone marrow stromal cells (hBMSC) spreading and differentiation. In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties
AB - To improve integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g. fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI’s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote human bone marrow stromal cells (hBMSC) spreading and differentiation. In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties
KW - coating
KW - stem cell
KW - whey protein isolate
KW - bone
KW - fibril
U2 - 10.3390/ijms21155544
DO - 10.3390/ijms21155544
M3 - Journal article
VL - 21
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 15
M1 - 5544
ER -