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Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils. / Rabe, Rebecca; Hempel, Ute; Martocq, Laurine et al.

In: International Journal of Molecular Sciences, Vol. 21, No. 15, 5544, 03.08.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Rabe, R, Hempel, U, Martocq, L, Keppler, JK, Aveyard, J & Douglas, T 2020, 'Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils', International Journal of Molecular Sciences, vol. 21, no. 15, 5544. https://doi.org/10.3390/ijms21155544

APA

Rabe, R., Hempel, U., Martocq, L., Keppler, J. K., Aveyard, J., & Douglas, T. (2020). Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils. International Journal of Molecular Sciences, 21(15), [5544]. https://doi.org/10.3390/ijms21155544

Vancouver

Rabe R, Hempel U, Martocq L, Keppler JK, Aveyard J, Douglas T. Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils. International Journal of Molecular Sciences. 2020 Aug 3;21(15):5544. doi: 10.3390/ijms21155544

Author

Rabe, Rebecca ; Hempel, Ute ; Martocq, Laurine et al. / Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils. In: International Journal of Molecular Sciences. 2020 ; Vol. 21, No. 15.

Bibtex

@article{38298ab6fdc44cedb97244b51c75cc6d,
title = "Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils",
abstract = "To improve integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g. fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI{\textquoteright}s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote human bone marrow stromal cells (hBMSC) spreading and differentiation. In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties",
keywords = "coating, stem cell, whey protein isolate, bone, fibril",
author = "Rebecca Rabe and Ute Hempel and Laurine Martocq and Keppler, {Julia K.} and Jenny Aveyard and Timothy Douglas",
year = "2020",
month = aug,
day = "3",
doi = "10.3390/ijms21155544",
language = "English",
volume = "21",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "15",

}

RIS

TY - JOUR

T1 - Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils

AU - Rabe, Rebecca

AU - Hempel, Ute

AU - Martocq, Laurine

AU - Keppler, Julia K.

AU - Aveyard, Jenny

AU - Douglas, Timothy

PY - 2020/8/3

Y1 - 2020/8/3

N2 - To improve integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g. fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI’s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote human bone marrow stromal cells (hBMSC) spreading and differentiation. In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties

AB - To improve integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g. fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI’s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote human bone marrow stromal cells (hBMSC) spreading and differentiation. In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties

KW - coating

KW - stem cell

KW - whey protein isolate

KW - bone

KW - fibril

U2 - 10.3390/ijms21155544

DO - 10.3390/ijms21155544

M3 - Journal article

VL - 21

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 15

M1 - 5544

ER -