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Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy

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Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy. / Lazaro-Pacheco, Daniela; Shaaban, Abeer; Baldwin, Gouri et al.

In: APPLIED SPECTROSCOPY REVIEWS, Vol. 57, No. 3, 16.03.2022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Lazaro-Pacheco, D, Shaaban, A, Baldwin, G, Titiloye, NA, Rehman, S & Rehman, IU 2022, 'Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy', APPLIED SPECTROSCOPY REVIEWS, vol. 57, no. 3. https://doi.org/10.1080/05704928.2020.1843471

APA

Lazaro-Pacheco, D., Shaaban, A., Baldwin, G., Titiloye, N. A., Rehman, S., & Rehman, I. U. (2022). Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy. APPLIED SPECTROSCOPY REVIEWS, 57(3). https://doi.org/10.1080/05704928.2020.1843471

Vancouver

Lazaro-Pacheco D, Shaaban A, Baldwin G, Titiloye NA, Rehman S, Rehman IU. Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy. APPLIED SPECTROSCOPY REVIEWS. 2022 Mar 16;57(3). Epub 2020 Nov 10. doi: 10.1080/05704928.2020.1843471

Author

Lazaro-Pacheco, Daniela ; Shaaban, Abeer ; Baldwin, Gouri et al. / Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy. In: APPLIED SPECTROSCOPY REVIEWS. 2022 ; Vol. 57, No. 3.

Bibtex

@article{e87c1f24eb38471ea2a87d01fdec5b67,
title = "Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy",
abstract = "A critical factor to favor a good prognosis in breast cancer (BC) patients is early detection. Offering prompt diagnosis, treatment, and delaying or stopping the progression of the disease are the key aspects of breast cancer management. The use of FTIR spectroscopy on ex vivo breast samples can elucidate important biochemical information associated with the presence and progression of breast cancer. In this study, tissue microarrays of breast cancer biopsy samples (n = 378), and normal breast (n = 134) were analyzed using FTIR spectroscopy, principal component analysis (PCA) for feature extraction, and validation employing linear discriminant analysis (LDA). The differentiation between normal breast and breast cancer was successfully achieved with a sensitivity of 92% and specificity of 86%. Lipids and proteins spectral bands were identified as the main differentiators between normal and breast cancer. FTIR results also highlighted that chemical structural changes formed an important part of breast cancer evolution. Regardless of the heterogeneity of breast cancer, the use of multivariate analysis and FTIR spectroscopy offers a suitable and reliable tool for BC monitoring and diagnosis. The integration of spectroscopic techniques such as FTIR in cancer diagnosis and monitoring could add useful information enabling the diagnosis and management of breast cancer patients.",
author = "Daniela Lazaro-Pacheco and Abeer Shaaban and Gouri Baldwin and Titiloye, {Nicholas Akinwale} and Shazza Rehman and Rehman, {Ihtesham ur}",
note = "This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record ",
year = "2022",
month = mar,
day = "16",
doi = "10.1080/05704928.2020.1843471",
language = "English",
volume = "57",
journal = "APPLIED SPECTROSCOPY REVIEWS",
issn = "0570-4928",
publisher = "Taylor and Francis Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Deciphering the structural and chemical composition of breast cancer using FTIR spectroscopy

AU - Lazaro-Pacheco, Daniela

AU - Shaaban, Abeer

AU - Baldwin, Gouri

AU - Titiloye, Nicholas Akinwale

AU - Rehman, Shazza

AU - Rehman, Ihtesham ur

N1 - This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record 

PY - 2022/3/16

Y1 - 2022/3/16

N2 - A critical factor to favor a good prognosis in breast cancer (BC) patients is early detection. Offering prompt diagnosis, treatment, and delaying or stopping the progression of the disease are the key aspects of breast cancer management. The use of FTIR spectroscopy on ex vivo breast samples can elucidate important biochemical information associated with the presence and progression of breast cancer. In this study, tissue microarrays of breast cancer biopsy samples (n = 378), and normal breast (n = 134) were analyzed using FTIR spectroscopy, principal component analysis (PCA) for feature extraction, and validation employing linear discriminant analysis (LDA). The differentiation between normal breast and breast cancer was successfully achieved with a sensitivity of 92% and specificity of 86%. Lipids and proteins spectral bands were identified as the main differentiators between normal and breast cancer. FTIR results also highlighted that chemical structural changes formed an important part of breast cancer evolution. Regardless of the heterogeneity of breast cancer, the use of multivariate analysis and FTIR spectroscopy offers a suitable and reliable tool for BC monitoring and diagnosis. The integration of spectroscopic techniques such as FTIR in cancer diagnosis and monitoring could add useful information enabling the diagnosis and management of breast cancer patients.

AB - A critical factor to favor a good prognosis in breast cancer (BC) patients is early detection. Offering prompt diagnosis, treatment, and delaying or stopping the progression of the disease are the key aspects of breast cancer management. The use of FTIR spectroscopy on ex vivo breast samples can elucidate important biochemical information associated with the presence and progression of breast cancer. In this study, tissue microarrays of breast cancer biopsy samples (n = 378), and normal breast (n = 134) were analyzed using FTIR spectroscopy, principal component analysis (PCA) for feature extraction, and validation employing linear discriminant analysis (LDA). The differentiation between normal breast and breast cancer was successfully achieved with a sensitivity of 92% and specificity of 86%. Lipids and proteins spectral bands were identified as the main differentiators between normal and breast cancer. FTIR results also highlighted that chemical structural changes formed an important part of breast cancer evolution. Regardless of the heterogeneity of breast cancer, the use of multivariate analysis and FTIR spectroscopy offers a suitable and reliable tool for BC monitoring and diagnosis. The integration of spectroscopic techniques such as FTIR in cancer diagnosis and monitoring could add useful information enabling the diagnosis and management of breast cancer patients.

U2 - 10.1080/05704928.2020.1843471

DO - 10.1080/05704928.2020.1843471

M3 - Journal article

VL - 57

JO - APPLIED SPECTROSCOPY REVIEWS

JF - APPLIED SPECTROSCOPY REVIEWS

SN - 0570-4928

IS - 3

ER -