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Deformation velocity imaging using optical coherence tomography and its applications to the cornea

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Deformation velocity imaging using optical coherence tomography and its applications to the cornea. / Lawman, Samuel; Madden, Peter W.; Romano, Vito et al.
In: Biomedical Optics Express, Vol. 8, No. 12, #302593, 01.12.2017, p. 5579-5593.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lawman, S, Madden, PW, Romano, V, Dong, Y, Mason, S, Williams, BM, Kaye, SB, Willoughby, CE, Harding, SP, Shen, YC & Zheng, Y 2017, 'Deformation velocity imaging using optical coherence tomography and its applications to the cornea', Biomedical Optics Express, vol. 8, no. 12, #302593, pp. 5579-5593. https://doi.org/10.1364/BOE.8.005579

APA

Lawman, S., Madden, P. W., Romano, V., Dong, Y., Mason, S., Williams, B. M., Kaye, S. B., Willoughby, C. E., Harding, S. P., Shen, Y. C., & Zheng, Y. (2017). Deformation velocity imaging using optical coherence tomography and its applications to the cornea. Biomedical Optics Express, 8(12), 5579-5593. Article #302593. https://doi.org/10.1364/BOE.8.005579

Vancouver

Lawman S, Madden PW, Romano V, Dong Y, Mason S, Williams BM et al. Deformation velocity imaging using optical coherence tomography and its applications to the cornea. Biomedical Optics Express. 2017 Dec 1;8(12):5579-5593. #302593. Epub 2017 Nov 13. doi: 10.1364/BOE.8.005579

Author

Lawman, Samuel ; Madden, Peter W. ; Romano, Vito et al. / Deformation velocity imaging using optical coherence tomography and its applications to the cornea. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 12. pp. 5579-5593.

Bibtex

@article{ded78277954d4eca8065ab38c45f065a,
title = "Deformation velocity imaging using optical coherence tomography and its applications to the cornea",
abstract = "Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.",
author = "Samuel Lawman and Madden, {Peter W.} and Vito Romano and Yue Dong and Sharon Mason and Williams, {Bryan M.} and Kaye, {Stephen B.} and Willoughby, {Colin E.} and Harding, {Simon P.} and Shen, {Yao Chun} and Yalin Zheng",
year = "2017",
month = dec,
day = "1",
doi = "10.1364/BOE.8.005579",
language = "English",
volume = "8",
pages = "5579--5593",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "12",

}

RIS

TY - JOUR

T1 - Deformation velocity imaging using optical coherence tomography and its applications to the cornea

AU - Lawman, Samuel

AU - Madden, Peter W.

AU - Romano, Vito

AU - Dong, Yue

AU - Mason, Sharon

AU - Williams, Bryan M.

AU - Kaye, Stephen B.

AU - Willoughby, Colin E.

AU - Harding, Simon P.

AU - Shen, Yao Chun

AU - Zheng, Yalin

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.

AB - Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.

U2 - 10.1364/BOE.8.005579

DO - 10.1364/BOE.8.005579

M3 - Journal article

AN - SCOPUS:85037343485

VL - 8

SP - 5579

EP - 5593

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 12

M1 - #302593

ER -