Dendritic receptors designed to bind polyanions in both organic and aqueous media

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Dendritic receptors designed to bind polyanions in both organic and aqueous media. / Hardy, John G.; Ashworth, Ian; Brennan, Colin et al.
In: Organic and Biomolecular Chemistry , Vol. 5, No. 6, 2007, p. 900-906.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hardy, JG, Ashworth, I, Brennan, C & Smith, DK 2007, 'Dendritic receptors designed to bind polyanions in both organic and aqueous media', Organic and Biomolecular Chemistry , vol. 5, no. 6, pp. 900-906. https://doi.org/10.1039/b618063a

APA

Hardy, J. G., Ashworth, I., Brennan, C., & Smith, D. K. (2007). Dendritic receptors designed to bind polyanions in both organic and aqueous media. Organic and Biomolecular Chemistry , 5(6), 900-906. https://doi.org/10.1039/b618063a

Vancouver

Hardy JG, Ashworth I, Brennan C, Smith DK. Dendritic receptors designed to bind polyanions in both organic and aqueous media. Organic and Biomolecular Chemistry . 2007;5(6):900-906. doi: 10.1039/b618063a

Author

Hardy, John G. ; Ashworth, Ian ; Brennan, Colin et al. / Dendritic receptors designed to bind polyanions in both organic and aqueous media. In: Organic and Biomolecular Chemistry . 2007 ; Vol. 5, No. 6. pp. 900-906.

Bibtex

@article{76d31c2d06d24f74a4345622a5352811,

title = "Dendritic receptors designed to bind polyanions in both organic and aqueous media",

abstract = "This paper reports the synthesis of dendrons containing a spermine unit at their focal point. The dendritic branching is based on L-lysine building blocks, and has terminal oligo(ethyleneglycol) units on the surface. As a consequence of the solubilising surface groups, these dendrons have high solubility in solvents with widely different polarities (e.g., dichloromethane and water). The protonated spermine unit at the focal point is an effective anion binding fragment and, as such, these dendrons are able to bind to polyanions. This paper demonstrates that polyanions can be bound in both dichloromethane (using a dye solubilisation assay) and in water (competitive ATP binding assay). In organic media the dendritic branching appears to have a pro-active effect on the solubilisation of the dye, with more dye being solubilised by higher generations of dendron. On the other hand, in water the degree of branching has no impact on the anion binding process. We propose that in this case, the spermine unit is effectively solvated by the bulk solvent and the dendritic branching does not need to play an active role in assisting solubility. Dendritic effects on anion binding have therefore been elucidated in different solvents. The dendritic branching plays a pro-active role in providing the anion binding unit with good solubility in apolar solvent media.",

keywords = "SUPRAMOLECULAR CHEMISTRY, BUILDING-BLOCKS, CONTROLLABLE NANOMATERIALS, SELECTIVE RECOGNITION, ANION RECEPTORS, DENDRIMERS, CORE, DENDRONS, DNA, SOLUBILIZATION, Chemistry(all), Biomaterials",

author = "Hardy, {John G.} and Ian Ashworth and Colin Brennan and Smith, {David K.}",

year = "2007",

doi = "10.1039/b618063a",

language = "English",

volume = "5",

pages = "900--906",

journal = "Organic and Biomolecular Chemistry ",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "6",

}

RIS

TY - JOUR

T1 - Dendritic receptors designed to bind polyanions in both organic and aqueous media

AU - Hardy, John G.

AU - Ashworth, Ian

AU - Brennan, Colin

AU - Smith, David K.

PY - 2007

Y1 - 2007

N2 - This paper reports the synthesis of dendrons containing a spermine unit at their focal point. The dendritic branching is based on L-lysine building blocks, and has terminal oligo(ethyleneglycol) units on the surface. As a consequence of the solubilising surface groups, these dendrons have high solubility in solvents with widely different polarities (e.g., dichloromethane and water). The protonated spermine unit at the focal point is an effective anion binding fragment and, as such, these dendrons are able to bind to polyanions. This paper demonstrates that polyanions can be bound in both dichloromethane (using a dye solubilisation assay) and in water (competitive ATP binding assay). In organic media the dendritic branching appears to have a pro-active effect on the solubilisation of the dye, with more dye being solubilised by higher generations of dendron. On the other hand, in water the degree of branching has no impact on the anion binding process. We propose that in this case, the spermine unit is effectively solvated by the bulk solvent and the dendritic branching does not need to play an active role in assisting solubility. Dendritic effects on anion binding have therefore been elucidated in different solvents. The dendritic branching plays a pro-active role in providing the anion binding unit with good solubility in apolar solvent media.

AB - This paper reports the synthesis of dendrons containing a spermine unit at their focal point. The dendritic branching is based on L-lysine building blocks, and has terminal oligo(ethyleneglycol) units on the surface. As a consequence of the solubilising surface groups, these dendrons have high solubility in solvents with widely different polarities (e.g., dichloromethane and water). The protonated spermine unit at the focal point is an effective anion binding fragment and, as such, these dendrons are able to bind to polyanions. This paper demonstrates that polyanions can be bound in both dichloromethane (using a dye solubilisation assay) and in water (competitive ATP binding assay). In organic media the dendritic branching appears to have a pro-active effect on the solubilisation of the dye, with more dye being solubilised by higher generations of dendron. On the other hand, in water the degree of branching has no impact on the anion binding process. We propose that in this case, the spermine unit is effectively solvated by the bulk solvent and the dendritic branching does not need to play an active role in assisting solubility. Dendritic effects on anion binding have therefore been elucidated in different solvents. The dendritic branching plays a pro-active role in providing the anion binding unit with good solubility in apolar solvent media.

KW - SUPRAMOLECULAR CHEMISTRY

KW - BUILDING-BLOCKS

KW - CONTROLLABLE NANOMATERIALS

KW - SELECTIVE RECOGNITION

KW - ANION RECEPTORS

KW - DENDRIMERS

KW - CORE

KW - DENDRONS

KW - DNA

KW - SOLUBILIZATION

KW - Chemistry(all)

KW - Biomaterials

U2 - 10.1039/b618063a

DO - 10.1039/b618063a

M3 - Journal article

VL - 5

SP - 900

EP - 906

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 6

ER -

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