Health and well-being factors significantly influence the flourishing of individuals and societies. in recent years, design researchers and practitioners have made an increasing and timely effort to respond to a variety of health and well-being challenges, from fostering a healthier digital lifestyle to tackling the adversities brought by the covid-19 pandemic. in this article, we reflect on the relationship between design, health and well-being, and how design can dedicatedly contribute to a better life through both identifying new possibilities and solving existing problems.