Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications

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Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications. / Istanbullu, H.; Ahmed, S.; Sheraz, M.A. et al.
In: Biomed Research International, Vol. 2013, 178973, 2013.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{7376ec513ffd4b369534f72ce2bbc133,

title = "Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications",

abstract = "The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1: 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1: 2 to 1: 5 ratios, respectively. {\textcopyright} 2013 Hilal Istanbullu et al.",

keywords = "polymer, polyurethan, solvent, tetrahydrofuran, tolfenamic acid, anthranilic acid derivative, article, differential scanning calorimetry, drug synthesis, infrared spectroscopy, scanning electron microscopy, X ray diffraction, chemistry, drug delivery system, synthesis, Calorimetry, Differential Scanning, Drug Delivery Systems, Microscopy, Electron, Scanning, ortho-Aminobenzoates, Polyurethanes, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction",

author = "H. Istanbullu and S. Ahmed and M.A. Sheraz and I.U. Rehman",

year = "2013",

doi = "10.1155/2013/178973",

language = "English",

volume = "2013",

journal = "Biomed Research International",

issn = "2314-6133",

publisher = "HINDAWI LTD",

}

RIS

TY - JOUR

T1 - Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications

AU - Istanbullu, H.

AU - Ahmed, S.

AU - Sheraz, M.A.

AU - Rehman, I.U.

PY - 2013

Y1 - 2013

N2 - The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1: 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1: 2 to 1: 5 ratios, respectively. © 2013 Hilal Istanbullu et al.

AB - The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1: 2 and 1: 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1: 2 to 1: 5 ratios, respectively. © 2013 Hilal Istanbullu et al.

KW - polymer

KW - polyurethan

KW - solvent

KW - tetrahydrofuran

KW - tolfenamic acid

KW - anthranilic acid derivative

KW - article

KW - differential scanning calorimetry

KW - drug synthesis

KW - infrared spectroscopy

KW - scanning electron microscopy

KW - X ray diffraction

KW - chemistry

KW - drug delivery system

KW - synthesis

KW - Calorimetry, Differential Scanning

KW - Drug Delivery Systems

KW - Microscopy, Electron, Scanning

KW - ortho-Aminobenzoates

KW - Polyurethanes

KW - Spectroscopy, Fourier Transform Infrared

KW - X-Ray Diffraction

U2 - 10.1155/2013/178973

DO - 10.1155/2013/178973

M3 - Journal article

VL - 2013

JO - Biomed Research International

JF - Biomed Research International

SN - 2314-6133

M1 - 178973

ER -

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