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Development of a multi frequency impedance measurement system for use in MEMS flow cytometers

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Development of a multi frequency impedance measurement system for use in MEMS flow cytometers. / Richardson, Andrew Mark David; Cole, Neil; Abdul‑Hafiz, Alako.
In: Microsystem Technologies, Vol. 23, No. 12, 12.2017, p. 5527-5543.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Richardson AMD, Cole N, Abdul‑Hafiz A. Development of a multi frequency impedance measurement system for use in MEMS flow cytometers. Microsystem Technologies. 2017 Dec;23(12):5527-5543. Epub 2017 Apr 17. doi: 10.1007/s00542-017-3359-z

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Richardson, Andrew Mark David ; Cole, Neil ; Abdul‑Hafiz, Alako. / Development of a multi frequency impedance measurement system for use in MEMS flow cytometers. In: Microsystem Technologies. 2017 ; Vol. 23, No. 12. pp. 5527-5543.

Bibtex

@article{c47b5c8658314ab0a596d7abfb297daa,
title = "Development of a multi frequency impedance measurement system for use in MEMS flow cytometers",
abstract = "A novel MEMS based system for flow cytometry is presented based on a multispectral approach. The solution provides the ability to concurrently generate, detect and analyse the response from a biological cell using multiple narrow band signals with a frequency separation sufficient to evoke different cellular responses. The narrow band approach limits the energy required and providesan improved signal to noise ratio for a given transmitter energy, avoiding wide band signal power dissipation and dilution issues. It requires only a single transmitter and receiver interface to the MEMS device with no duplication of analogue signal paths. The design has the ability to generate a complex multi frequency waveform with a wide frequency separation. A digital approach based on the CORDIC algorithm (Volder, IRE Trans Electron Comput EC-8:330–334, 1959) was used to generate the required sinusoidal waveforms. The digital section of the design was implemented on an FPGA. It utilised a modified digital phase sensitive amplifier to provide enhanced signal tonoise performance and harmonic rejection. A novel hybrid, cross channel electrode structure to implement the stimulus and response analysis sub-system has been designed.A fully functional macroscopic test bench has been constructed to demonstrate the viability of the approach. Both physical measurements and finite element data has been used to demonstrate the potential for migration into a MEMS based system.",
keywords = "Microfluidics, MEMS, Flow Cytometer, Electrodes",
author = "Richardson, {Andrew Mark David} and Neil Cole and Alako Abdul‑Hafiz",
year = "2017",
month = dec,
doi = "10.1007/s00542-017-3359-z",
language = "English",
volume = "23",
pages = "5527--5543",
journal = "Microsystem Technologies",
issn = "0946-7076",
publisher = "Springer Verlag",
number = "12",

}

RIS

TY - JOUR

T1 - Development of a multi frequency impedance measurement system for use in MEMS flow cytometers

AU - Richardson, Andrew Mark David

AU - Cole, Neil

AU - Abdul‑Hafiz, Alako

PY - 2017/12

Y1 - 2017/12

N2 - A novel MEMS based system for flow cytometry is presented based on a multispectral approach. The solution provides the ability to concurrently generate, detect and analyse the response from a biological cell using multiple narrow band signals with a frequency separation sufficient to evoke different cellular responses. The narrow band approach limits the energy required and providesan improved signal to noise ratio for a given transmitter energy, avoiding wide band signal power dissipation and dilution issues. It requires only a single transmitter and receiver interface to the MEMS device with no duplication of analogue signal paths. The design has the ability to generate a complex multi frequency waveform with a wide frequency separation. A digital approach based on the CORDIC algorithm (Volder, IRE Trans Electron Comput EC-8:330–334, 1959) was used to generate the required sinusoidal waveforms. The digital section of the design was implemented on an FPGA. It utilised a modified digital phase sensitive amplifier to provide enhanced signal tonoise performance and harmonic rejection. A novel hybrid, cross channel electrode structure to implement the stimulus and response analysis sub-system has been designed.A fully functional macroscopic test bench has been constructed to demonstrate the viability of the approach. Both physical measurements and finite element data has been used to demonstrate the potential for migration into a MEMS based system.

AB - A novel MEMS based system for flow cytometry is presented based on a multispectral approach. The solution provides the ability to concurrently generate, detect and analyse the response from a biological cell using multiple narrow band signals with a frequency separation sufficient to evoke different cellular responses. The narrow band approach limits the energy required and providesan improved signal to noise ratio for a given transmitter energy, avoiding wide band signal power dissipation and dilution issues. It requires only a single transmitter and receiver interface to the MEMS device with no duplication of analogue signal paths. The design has the ability to generate a complex multi frequency waveform with a wide frequency separation. A digital approach based on the CORDIC algorithm (Volder, IRE Trans Electron Comput EC-8:330–334, 1959) was used to generate the required sinusoidal waveforms. The digital section of the design was implemented on an FPGA. It utilised a modified digital phase sensitive amplifier to provide enhanced signal tonoise performance and harmonic rejection. A novel hybrid, cross channel electrode structure to implement the stimulus and response analysis sub-system has been designed.A fully functional macroscopic test bench has been constructed to demonstrate the viability of the approach. Both physical measurements and finite element data has been used to demonstrate the potential for migration into a MEMS based system.

KW - Microfluidics

KW - MEMS

KW - Flow Cytometer

KW - Electrodes

U2 - 10.1007/s00542-017-3359-z

DO - 10.1007/s00542-017-3359-z

M3 - Journal article

VL - 23

SP - 5527

EP - 5543

JO - Microsystem Technologies

JF - Microsystem Technologies

SN - 0946-7076

IS - 12

ER -