Sustainable development comes along with green chemistry since it integrates renewable sources as well as processes in harmony, yielding biodegradable, nontoxic, and cost-efficient products. Thanks to the advancement of the molecular imprinting approach, molecularly imprinted polymers (MIPs) become attractive technology, and now, they are commonly applied in various fields including the pharmaceutical and biomedical industries. However, the future projection of MIPs depends on to what extent they meet sustainability. Considering the adverse effects of the ingredients of MIPs on the ecosystem, it seems inevitable for those ingredients replaced by their green counterparts. This chapter aims to provide strategies for enhancing the green aspect of MIPs by focusing on alternative green ingredients and highlighting a brief presentation of MIPs. Through the chapter, potential chemicals and production methods are addressed according to their relevance for green chemistry principles while shortening its scope to environmental and food safety applications.