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Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-κB homologue

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Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-κB homologue. / Richardson, Jill C.; Gatherer, Derek; Woodland, Hugh R.

In: Mechanisms of Development, Vol. 52, No. 2-3, 08.1995, p. 165-177.

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Richardson, Jill C. ; Gatherer, Derek ; Woodland, Hugh R. / Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-κB homologue. In: Mechanisms of Development. 1995 ; Vol. 52, No. 2-3. pp. 165-177.

Bibtex

@article{f33157c30dc149e5bfe115041254c60c,
title = "Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-κB homologue",
abstract = "High level over-expression of XrelA1, a homologue of the p65 sub-unit of NF-kappa B and of Drosophila dorsal, arrests Xenopus development at the gastrula stage, producing a reduction in the levels of expression of various genes of developmental interest without general reduction in transcription or cessation of cell division. There is little Goosecoid expression, even though a dorsal lip forms. At lower levels XrelA1 mRNA primarily produces disruption of the mid-dorsal axis. A dominant interference gene product, Delta 222, produces mainly posterior, but also anterior abnormalities. On the basis of these results we postulate that the role of XrelA1 in the vertebrate embryo is unlikely to be in dorsoventral development, but more likely in the formation of the termini.",
keywords = "XENOPUS, NF-KAPPA-B, DORSAL, AXIS FORMATION, DROSOPHILA EMBRYO, DORSOVENTRAL PATTERN, MESODERM INDUCTION, NEURAL INDUCTION, DORSAL PROTEIN, ORGANIZER, CACTUS, LAEVIS, SPECIFICATION, MORPHOGEN",
author = "Richardson, {Jill C.} and Derek Gatherer and Woodland, {Hugh R.}",
year = "1995",
month = aug,
doi = "10.1016/0925-4773(95)00388-H",
language = "English",
volume = "52",
pages = "165--177",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

RIS

TY - JOUR

T1 - Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-κB homologue

AU - Richardson, Jill C.

AU - Gatherer, Derek

AU - Woodland, Hugh R.

PY - 1995/8

Y1 - 1995/8

N2 - High level over-expression of XrelA1, a homologue of the p65 sub-unit of NF-kappa B and of Drosophila dorsal, arrests Xenopus development at the gastrula stage, producing a reduction in the levels of expression of various genes of developmental interest without general reduction in transcription or cessation of cell division. There is little Goosecoid expression, even though a dorsal lip forms. At lower levels XrelA1 mRNA primarily produces disruption of the mid-dorsal axis. A dominant interference gene product, Delta 222, produces mainly posterior, but also anterior abnormalities. On the basis of these results we postulate that the role of XrelA1 in the vertebrate embryo is unlikely to be in dorsoventral development, but more likely in the formation of the termini.

AB - High level over-expression of XrelA1, a homologue of the p65 sub-unit of NF-kappa B and of Drosophila dorsal, arrests Xenopus development at the gastrula stage, producing a reduction in the levels of expression of various genes of developmental interest without general reduction in transcription or cessation of cell division. There is little Goosecoid expression, even though a dorsal lip forms. At lower levels XrelA1 mRNA primarily produces disruption of the mid-dorsal axis. A dominant interference gene product, Delta 222, produces mainly posterior, but also anterior abnormalities. On the basis of these results we postulate that the role of XrelA1 in the vertebrate embryo is unlikely to be in dorsoventral development, but more likely in the formation of the termini.

KW - XENOPUS

KW - NF-KAPPA-B

KW - DORSAL

KW - AXIS FORMATION

KW - DROSOPHILA EMBRYO

KW - DORSOVENTRAL PATTERN

KW - MESODERM INDUCTION

KW - NEURAL INDUCTION

KW - DORSAL PROTEIN

KW - ORGANIZER

KW - CACTUS

KW - LAEVIS

KW - SPECIFICATION

KW - MORPHOGEN

U2 - 10.1016/0925-4773(95)00388-H

DO - 10.1016/0925-4773(95)00388-H

M3 - Journal article

VL - 52

SP - 165

EP - 177

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 2-3

ER -