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Different forms of effective connectivity in primate frontotemporal pathways

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Different forms of effective connectivity in primate frontotemporal pathways. / Petkov, Christopher I.; Kikuchi, Yukiko; Milne, Alice E. et al.
In: Nature Communications, Vol. 6, 6000, 28.02.2015.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Petkov, CI, Kikuchi, Y, Milne, AE, Mishkin, M, Rauschecker, JP & Logothetis, NK 2015, 'Different forms of effective connectivity in primate frontotemporal pathways', Nature Communications, vol. 6, 6000. https://doi.org/10.1038/ncomms7000

APA

Petkov, C. I., Kikuchi, Y., Milne, A. E., Mishkin, M., Rauschecker, J. P., & Logothetis, N. K. (2015). Different forms of effective connectivity in primate frontotemporal pathways. Nature Communications, 6, Article 6000. https://doi.org/10.1038/ncomms7000

Vancouver

Petkov CI, Kikuchi Y, Milne AE, Mishkin M, Rauschecker JP, Logothetis NK. Different forms of effective connectivity in primate frontotemporal pathways. Nature Communications. 2015 Feb 28;6:6000. Epub 2015 Jan 23. doi: 10.1038/ncomms7000

Author

Petkov, Christopher I. ; Kikuchi, Yukiko ; Milne, Alice E. et al. / Different forms of effective connectivity in primate frontotemporal pathways. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{998cdf64c0404cc8a2b262cafcb72dd6,
title = "Different forms of effective connectivity in primate frontotemporal pathways",
abstract = "It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.",
author = "Petkov, {Christopher I.} and Yukiko Kikuchi and Milne, {Alice E.} and Mortimer Mishkin and Rauschecker, {Josef P.} and Logothetis, {Nikos K.}",
year = "2015",
month = feb,
day = "28",
doi = "10.1038/ncomms7000",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Different forms of effective connectivity in primate frontotemporal pathways

AU - Petkov, Christopher I.

AU - Kikuchi, Yukiko

AU - Milne, Alice E.

AU - Mishkin, Mortimer

AU - Rauschecker, Josef P.

AU - Logothetis, Nikos K.

PY - 2015/2/28

Y1 - 2015/2/28

N2 - It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.

AB - It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.

U2 - 10.1038/ncomms7000

DO - 10.1038/ncomms7000

M3 - Journal article

C2 - 25613079

AN - SCOPUS:84923172408

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 6000

ER -