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Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. / Alders, M.; Ryan, A.; Hodges, Matt et al.
In: American Journal of Human Genetics, Vol. 66, No. 5, 05.2000, p. 1473-1484.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Alders, M, Ryan, A, Hodges, M, Bliek, J, Feinberg, AP, Privitera, O, Westerveld, A, Little, PFR & Mannens, M 2000, 'Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.', American Journal of Human Genetics, vol. 66, no. 5, pp. 1473-1484. https://doi.org/10.1086/302892

APA

Alders, M., Ryan, A., Hodges, M., Bliek, J., Feinberg, A. P., Privitera, O., Westerveld, A., Little, P. F. R., & Mannens, M. (2000). Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. American Journal of Human Genetics, 66(5), 1473-1484. https://doi.org/10.1086/302892

Vancouver

Alders M, Ryan A, Hodges M, Bliek J, Feinberg AP, Privitera O et al. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. American Journal of Human Genetics. 2000 May;66(5):1473-1484. doi: 10.1086/302892

Author

Alders, M. ; Ryan, A. ; Hodges, Matt et al. / Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. In: American Journal of Human Genetics. 2000 ; Vol. 66, No. 5. pp. 1473-1484.

Bibtex

@article{182a8e3fe8a543c1abbdbdbdc286d736,
title = "Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.",
abstract = "The genetics of Beckwith-Wiedemann syndrome (BWS) is complex and is thought to involve multiple genes. It is known that three regions on chromosome 11p15 (BWSCR1, BWSCR2, and BWSCR3) may play a role in the development of BWS. BWSCR2 is defined by two BWS breakpoints. Here we describe the cloning and sequence analysis of 73 kb containing BWSCR2. Within this region, we detected a novel zinc-finger gene, ZNF215. We show that two of its five alternatively spliced transcripts are disrupted by both BWSCR2 breakpoints. Parts of the 3′ end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214. We show that ZNF215 is imprinted in a tissue-specific manner.",
keywords = "BWS, ZNF215",
author = "M. Alders and A. Ryan and Matt Hodges and J. Bliek and Feinberg, {A. P.} and O. Privitera and A. Westerveld and Little, {P. F. R.} and M. Mannens",
year = "2000",
month = may,
doi = "10.1086/302892",
language = "English",
volume = "66",
pages = "1473--1484",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.

AU - Alders, M.

AU - Ryan, A.

AU - Hodges, Matt

AU - Bliek, J.

AU - Feinberg, A. P.

AU - Privitera, O.

AU - Westerveld, A.

AU - Little, P. F. R.

AU - Mannens, M.

PY - 2000/5

Y1 - 2000/5

N2 - The genetics of Beckwith-Wiedemann syndrome (BWS) is complex and is thought to involve multiple genes. It is known that three regions on chromosome 11p15 (BWSCR1, BWSCR2, and BWSCR3) may play a role in the development of BWS. BWSCR2 is defined by two BWS breakpoints. Here we describe the cloning and sequence analysis of 73 kb containing BWSCR2. Within this region, we detected a novel zinc-finger gene, ZNF215. We show that two of its five alternatively spliced transcripts are disrupted by both BWSCR2 breakpoints. Parts of the 3′ end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214. We show that ZNF215 is imprinted in a tissue-specific manner.

AB - The genetics of Beckwith-Wiedemann syndrome (BWS) is complex and is thought to involve multiple genes. It is known that three regions on chromosome 11p15 (BWSCR1, BWSCR2, and BWSCR3) may play a role in the development of BWS. BWSCR2 is defined by two BWS breakpoints. Here we describe the cloning and sequence analysis of 73 kb containing BWSCR2. Within this region, we detected a novel zinc-finger gene, ZNF215. We show that two of its five alternatively spliced transcripts are disrupted by both BWSCR2 breakpoints. Parts of the 3′ end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214. We show that ZNF215 is imprinted in a tissue-specific manner.

KW - BWS

KW - ZNF215

U2 - 10.1086/302892

DO - 10.1086/302892

M3 - Journal article

VL - 66

SP - 1473

EP - 1484

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 5

ER -