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Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine.

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Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. / Jones, Steven H.; Hemsley, D.; Ball, S. et al.
In: Behavioural Brain Research, Vol. 88, No. 1, 1997, p. 103-114.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Jones, SH, Hemsley, D, Ball, S & Serra, A 1997, 'Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine.', Behavioural Brain Research, vol. 88, no. 1, pp. 103-114. https://doi.org/10.1016/S0166-4328(97)02312-7

APA

Jones, S. H., Hemsley, D., Ball, S., & Serra, A. (1997). Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. Behavioural Brain Research, 88(1), 103-114. https://doi.org/10.1016/S0166-4328(97)02312-7

Vancouver

Jones SH, Hemsley, D, Ball, S, Serra A. Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. Behavioural Brain Research. 1997;88(1):103-114. doi: 10.1016/S0166-4328(97)02312-7

Author

Jones, Steven H. ; Hemsley, D. ; Ball, S. et al. / Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine. In: Behavioural Brain Research. 1997 ; Vol. 88, No. 1. pp. 103-114.

Bibtex

@article{bed04c75c172464095fc82d6ccc6aaaf,
title = "Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine.",
abstract = "The Kamin blocking effect (KBE) is an established animal learning paradigm measuring selective processing, in which reduced blocking reflects allocation of greater processing resources to non-relevant information. Two KBE tasks are described below. Results from studies using the first (between-subjects) task indicate that KBE is abolished in acute schizophrenics with positive psychotic symptoms. It is also abolished in the relatives of schizophrenic subjects, although interpretation of this finding is hampered by poor performance of subjects in the control condition. The second (within-subjects) task indicated abolition of KBE in schizophrenic patients with positive psychotic symptoms. Administration of acute amphetamine to normal human subjects did not significantly disrupt performance on the first task. Whilst for the second task, although blocking was limited to placebo subjects, overall pre-exposure effects are not sufficiently strong to indicate specific drug effects.",
keywords = "Schizophrenia, Associative learning, Amphetamine, Blocking, Animal models",
author = "Jones, {Steven H.} and D. Hemsley, and S. Ball, and A. Serra",
year = "1997",
doi = "10.1016/S0166-4328(97)02312-7",
language = "English",
volume = "88",
pages = "103--114",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Disruption of the Kamin blocking effect in schizophrenia and in normal subjects following amphetamine.

AU - Jones, Steven H.

AU - Hemsley,, D.

AU - Ball,, S.

AU - Serra, A.

PY - 1997

Y1 - 1997

N2 - The Kamin blocking effect (KBE) is an established animal learning paradigm measuring selective processing, in which reduced blocking reflects allocation of greater processing resources to non-relevant information. Two KBE tasks are described below. Results from studies using the first (between-subjects) task indicate that KBE is abolished in acute schizophrenics with positive psychotic symptoms. It is also abolished in the relatives of schizophrenic subjects, although interpretation of this finding is hampered by poor performance of subjects in the control condition. The second (within-subjects) task indicated abolition of KBE in schizophrenic patients with positive psychotic symptoms. Administration of acute amphetamine to normal human subjects did not significantly disrupt performance on the first task. Whilst for the second task, although blocking was limited to placebo subjects, overall pre-exposure effects are not sufficiently strong to indicate specific drug effects.

AB - The Kamin blocking effect (KBE) is an established animal learning paradigm measuring selective processing, in which reduced blocking reflects allocation of greater processing resources to non-relevant information. Two KBE tasks are described below. Results from studies using the first (between-subjects) task indicate that KBE is abolished in acute schizophrenics with positive psychotic symptoms. It is also abolished in the relatives of schizophrenic subjects, although interpretation of this finding is hampered by poor performance of subjects in the control condition. The second (within-subjects) task indicated abolition of KBE in schizophrenic patients with positive psychotic symptoms. Administration of acute amphetamine to normal human subjects did not significantly disrupt performance on the first task. Whilst for the second task, although blocking was limited to placebo subjects, overall pre-exposure effects are not sufficiently strong to indicate specific drug effects.

KW - Schizophrenia

KW - Associative learning

KW - Amphetamine

KW - Blocking

KW - Animal models

U2 - 10.1016/S0166-4328(97)02312-7

DO - 10.1016/S0166-4328(97)02312-7

M3 - Journal article

VL - 88

SP - 103

EP - 114

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -