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Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. / Griffin, John M.; Martin, Dave R.; Brown, Steven P.
In: Angewandte Chemie International Edition, Vol. 46, No. 42, 22.10.2007, p. 8036-8038.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Griffin, JM, Martin, DR & Brown, SP 2007, 'Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy', Angewandte Chemie International Edition, vol. 46, no. 42, pp. 8036-8038. https://doi.org/10.1002/anie.200702582

APA

Griffin, J. M., Martin, D. R., & Brown, S. P. (2007). Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. Angewandte Chemie International Edition, 46(42), 8036-8038. https://doi.org/10.1002/anie.200702582

Vancouver

Griffin JM, Martin DR, Brown SP. Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. Angewandte Chemie International Edition. 2007 Oct 22;46(42):8036-8038. Epub 2007 Sept 11. doi: 10.1002/anie.200702582

Author

Griffin, John M. ; Martin, Dave R. ; Brown, Steven P. / Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. In: Angewandte Chemie International Edition. 2007 ; Vol. 46, No. 42. pp. 8036-8038.

Bibtex

@article{180eaebc11c84ce08db0408c4b70fb8f,
title = "Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy",
abstract = "With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.",
keywords = "analytical methods, drug design, NMR spectroscopy, polymorphism, PROTON-PROTON PROXIMITIES, H-1-H-1 DOUBLE-QUANTUM, POLYMORPHISM, DYNAMICS, PULSE",
author = "Griffin, {John M.} and Martin, {Dave R.} and Brown, {Steven P.}",
year = "2007",
month = oct,
day = "22",
doi = "10.1002/anie.200702582",
language = "English",
volume = "46",
pages = "8036--8038",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag",
number = "42",

}

RIS

TY - JOUR

T1 - Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy

AU - Griffin, John M.

AU - Martin, Dave R.

AU - Brown, Steven P.

PY - 2007/10/22

Y1 - 2007/10/22

N2 - With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.

AB - With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.

KW - analytical methods

KW - drug design

KW - NMR spectroscopy

KW - polymorphism

KW - PROTON-PROTON PROXIMITIES

KW - H-1-H-1 DOUBLE-QUANTUM

KW - POLYMORPHISM

KW - DYNAMICS

KW - PULSE

U2 - 10.1002/anie.200702582

DO - 10.1002/anie.200702582

M3 - Journal article

VL - 46

SP - 8036

EP - 8038

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 42

ER -