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  • Crawford_ID_WM_dissociation_Neuropsychologia_Nov_2015_resubmission_v8_

    Rights statement: This is the author’s version of a work that was accepted for publication in Neuropsychologia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuropsychologia, 81, 2016 DOI: 10.1016/j.neuropsychologia.2015.12.007

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Distinguishing between impairments of working memory and inhibitory control in cases of early dementia

Research output: Contribution to journalJournal articlepeer-review

Published
<mark>Journal publication date</mark>29/01/2016
<mark>Journal</mark>Neuropsychologia
Volume81
Number of pages7
Pages (from-to)61-67
Publication StatusPublished
Early online date11/12/15
<mark>Original language</mark>English

Abstract

Dementia (most notably, Alzheimer’s Disease) is often associated with impairments of both working memory and inhibitory control. However, it is unclear whether these are functionally distinct impairments. We addressed the issue of whether working memory and inhibitory control can be dissociated, using data from a sample of patients who were recruited in a longitudinal study (Crawford et al. 2013, 2015). The first case revealed a preserved working memory capacity together with poor inhibitory control in the anti-saccade task. A longitudinal follow-up revealed that the defective inhibitory control emerged 12-months before the dementia was evident on the mini-mental state examination assessment. A second case revealed a poor working memory together with a well-preserved level of inhibitory control. The dissociation of working memory and inhibitory control was confirmed statistically in 7 additional cases. These findings yield converging evidence that working memory and inhibitory control are distinct cognitive operations and challenges the Kimberg and Farah (2000) cognitive model of working memory.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Neuropsychologia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuropsychologia, 81, 2016 DOI: 10.1016/j.neuropsychologia.2015.12.007