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Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS).

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Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS). / Lanza, Matteo; Acton, Joe; Jürschik, Simone; Sulzer, Philipp; Breiev, Kostiantyn; Jordan, Alfons; Hartungen, Eugen; Hanel, Gernot; Märk, Lukas; Mayhew, Chris A.; Märk, Tilmann D.

In: Journal of Mass Spectrometry, Vol. 48, No. 9, 09.2013, p. 1015-1018.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Lanza, M, Acton, J, Jürschik, S, Sulzer, P, Breiev, K, Jordan, A, Hartungen, E, Hanel, G, Märk, L, Mayhew, CA & Märk, TD 2013, 'Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS).', Journal of Mass Spectrometry, vol. 48, no. 9, pp. 1015-1018. https://doi.org/10.1002/jms.3253

APA

Lanza, M., Acton, J., Jürschik, S., Sulzer, P., Breiev, K., Jordan, A., Hartungen, E., Hanel, G., Märk, L., Mayhew, C. A., & Märk, T. D. (2013). Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS). Journal of Mass Spectrometry, 48(9), 1015-1018. https://doi.org/10.1002/jms.3253

Vancouver

Lanza M, Acton J, Jürschik S, Sulzer P, Breiev K, Jordan A et al. Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS). Journal of Mass Spectrometry. 2013 Sep;48(9):1015-1018. https://doi.org/10.1002/jms.3253

Author

Lanza, Matteo ; Acton, Joe ; Jürschik, Simone ; Sulzer, Philipp ; Breiev, Kostiantyn ; Jordan, Alfons ; Hartungen, Eugen ; Hanel, Gernot ; Märk, Lukas ; Mayhew, Chris A. ; Märk, Tilmann D. / Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS). In: Journal of Mass Spectrometry. 2013 ; Vol. 48, No. 9. pp. 1015-1018.

Bibtex

@article{ead3be2aba0d46858e5f5fee79eee3a5,
title = "Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS).",
abstract = "The isomers 4-methylethcathinone and N-ethylbuphedrone are substitutes for the recently banned drug mephedrone. We find that with conventional proton transfer reaction mass spectrometry (PTR-MS), it is not possible to distinguish between these two isomers, because essentially for both substances, only the protonated molecules are observed at a mass-to-charge ratio of 192 (C12 H18 NO(+) ). However, when utilising an advanced PTR-MS instrument that allows us to switch the reagent ions (selective reagent ionisation) from H3 O(+) (which is commonly used in PTR-MS) to NO(+) , O2 (+) and Kr(+) , characteristic product (fragment) ions are detected: C4 H10 N(+) (72 Da) for 4-methylethcathinone and C5 H12 N(+) (86 Da) for N-ethylbuphedrone; thus, selective reagent ionisation MS proves to be a powerful tool for fast detection and identification of these compounds. ",
keywords = "SRI-MS, PTR-MS, mephedrone, new psychoactive substances, designer drugs",
author = "Matteo Lanza and Joe Acton and Simone J{\"u}rschik and Philipp Sulzer and Kostiantyn Breiev and Alfons Jordan and Eugen Hartungen and Gernot Hanel and Lukas M{\"a}rk and Mayhew, {Chris A.} and M{\"a}rk, {Tilmann D.}",
year = "2013",
month = sep,
doi = "10.1002/jms.3253",
language = "English",
volume = "48",
pages = "1015--1018",
journal = "Journal of Mass Spectrometry",
issn = "1076-5174",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS).

AU - Lanza, Matteo

AU - Acton, Joe

AU - Jürschik, Simone

AU - Sulzer, Philipp

AU - Breiev, Kostiantyn

AU - Jordan, Alfons

AU - Hartungen, Eugen

AU - Hanel, Gernot

AU - Märk, Lukas

AU - Mayhew, Chris A.

AU - Märk, Tilmann D.

PY - 2013/9

Y1 - 2013/9

N2 - The isomers 4-methylethcathinone and N-ethylbuphedrone are substitutes for the recently banned drug mephedrone. We find that with conventional proton transfer reaction mass spectrometry (PTR-MS), it is not possible to distinguish between these two isomers, because essentially for both substances, only the protonated molecules are observed at a mass-to-charge ratio of 192 (C12 H18 NO(+) ). However, when utilising an advanced PTR-MS instrument that allows us to switch the reagent ions (selective reagent ionisation) from H3 O(+) (which is commonly used in PTR-MS) to NO(+) , O2 (+) and Kr(+) , characteristic product (fragment) ions are detected: C4 H10 N(+) (72 Da) for 4-methylethcathinone and C5 H12 N(+) (86 Da) for N-ethylbuphedrone; thus, selective reagent ionisation MS proves to be a powerful tool for fast detection and identification of these compounds.

AB - The isomers 4-methylethcathinone and N-ethylbuphedrone are substitutes for the recently banned drug mephedrone. We find that with conventional proton transfer reaction mass spectrometry (PTR-MS), it is not possible to distinguish between these two isomers, because essentially for both substances, only the protonated molecules are observed at a mass-to-charge ratio of 192 (C12 H18 NO(+) ). However, when utilising an advanced PTR-MS instrument that allows us to switch the reagent ions (selective reagent ionisation) from H3 O(+) (which is commonly used in PTR-MS) to NO(+) , O2 (+) and Kr(+) , characteristic product (fragment) ions are detected: C4 H10 N(+) (72 Da) for 4-methylethcathinone and C5 H12 N(+) (86 Da) for N-ethylbuphedrone; thus, selective reagent ionisation MS proves to be a powerful tool for fast detection and identification of these compounds.

KW - SRI-MS

KW - PTR-MS

KW - mephedrone

KW - new psychoactive substances

KW - designer drugs

U2 - 10.1002/jms.3253

DO - 10.1002/jms.3253

M3 - Journal article

VL - 48

SP - 1015

EP - 1018

JO - Journal of Mass Spectrometry

JF - Journal of Mass Spectrometry

SN - 1076-5174

IS - 9

ER -