The Weiyuan and Anyue large gas fields discovered on the Leshan-Longnvsi paleo-uplift in Sichuan Basin have the oldest marine gas reservoir discovered in China so far, and Weiyuan is also the first gas field to utilize helium resources in China. The Helium in natural gas of Leshan-Longnvsi paleo-uplift belongs to crust-derived helium formed by radioactivity, and its content distribution shows obvious regularity. The content of helium is highly correlated with the age of reservoir in the same gas field, and the helium content is gradually increased from the top to the bottom. However, the content of helium in natural gas presents significantly different in various tectonic units. The content of helium in Anyue gas field developed on Gaoshiti-Moxi structure is very low. The average contents of Sinian and Cambrian are 0.0356% and 0.0078%, respectively. The content of helium in Weiyuan gas field developed on Weiyuan structure is relatively higher, and the average contents of Sinian and Cambrian are 0.28% and 0.18% respectively. The high helium content of natural gas in Weiyuan gas field is related to the large-scale granite body developed on the basement on the one hand and the water-soluble gas accumulation on the other hand. The main gas reservoirs in the Weiyuan gas field and adjacent areas are located in the Sinian system. From the slope area to the high point of the Weiyuan structure, the helium content has increased significantly. With the tectonic movement of the Himalayan period, the Weiyuan area is greatly uplifted, causing structural traps. Natural gas dissolved in the water, including helium gas, is decomposed by decompression, and the released gas is trapped, then released gases accumulated in traps and thus formed Weiyuan gas field with high content of helium.