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    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.0c01696

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DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China

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DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China. / Wan, C.; Pan, S.; Lin, L. et al.

In: Environmental Science and Technology, Vol. 55, No. 1, 05.01.2021, p. 412-422.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Wan, C, Pan, S, Lin, L, Li, J, Dong, G, Jones, KC, Liu, F, Li, D, Liu, J, Yu, Z, Zhang, G & Ma, H 2021, 'DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China', Environmental Science and Technology, vol. 55, no. 1, pp. 412-422. https://doi.org/10.1021/acs.est.0c01696

APA

Wan, C., Pan, S., Lin, L., Li, J., Dong, G., Jones, K. C., Liu, F., Li, D., Liu, J., Yu, Z., Zhang, G., & Ma, H. (2021). DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China. Environmental Science and Technology, 55(1), 412-422. https://doi.org/10.1021/acs.est.0c01696

Vancouver

Wan C, Pan S, Lin L, Li J, Dong G, Jones KC et al. DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China. Environmental Science and Technology. 2021 Jan 5;55(1):412-422. Epub 2020 Dec 8. doi: 10.1021/acs.est.0c01696

Author

Wan, C. ; Pan, S. ; Lin, L. et al. / DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China. In: Environmental Science and Technology. 2021 ; Vol. 55, No. 1. pp. 412-422.

Bibtex

@article{28fa2fe02bfe4aa4868bbafbcf7592f3,
title = "DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China",
abstract = "Although lead associated with intelligence decline in children has long been reported, studies combining intelligence determination, molecular mechanisms exploration, and biomarker screen are quite rare. In this study, based on 333 children aged 9-11, we determined the role of DNA methylation (DNAm) in the relationship of lead exposure with children's intelligence. DNAm was measured from children's blood DNA specimens, and mediation analysis was performed to identify DNAm biomarkers mediating the lead-intelligence relationship. We identified forty-three differentially methylated regions (DMRs), and two fragments (FAM50B1 and PTCHD3) significantly mediated the lead-intelligence relationship, with contribution rates of 30.36% (p = 0.010) and 60.36% (p <0.001), respectively. In addition, blood lead levels (BLLs) lower than 100 μg/L still adversely affected children's IQs and DNAm of the two fragments. Our data suggests that DNAm mediates lead-associated cognitive delay in children and blood lead reference value for school-aged children (100 μg/L) should be revised, and the candidate biomarkers can be used in related neurological diseases in future. ",
keywords = "biomarkers, blood lead, children's intelligence, DNA methylation, FAM50B1, PTCHD3, Alkylation, Blood, DNA, Methylation, Blood lead level (BLLs), Contribution rate, DNA Methylation, Mediation analysis, Molecular mechanism, Neurological disease, Reference values, Southern China, Biomarkers",
author = "C. Wan and S. Pan and L. Lin and J. Li and G. Dong and K.C. Jones and F. Liu and D. Li and J. Liu and Z. Yu and G. Zhang and H. Ma",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright {\textcopyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.0c01696",
year = "2021",
month = jan,
day = "5",
doi = "10.1021/acs.est.0c01696",
language = "English",
volume = "55",
pages = "412--422",
journal = "Environmental Science and Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "1",

}

RIS

TY - JOUR

T1 - DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China

AU - Wan, C.

AU - Pan, S.

AU - Lin, L.

AU - Li, J.

AU - Dong, G.

AU - Jones, K.C.

AU - Liu, F.

AU - Li, D.

AU - Liu, J.

AU - Yu, Z.

AU - Zhang, G.

AU - Ma, H.

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.0c01696

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Although lead associated with intelligence decline in children has long been reported, studies combining intelligence determination, molecular mechanisms exploration, and biomarker screen are quite rare. In this study, based on 333 children aged 9-11, we determined the role of DNA methylation (DNAm) in the relationship of lead exposure with children's intelligence. DNAm was measured from children's blood DNA specimens, and mediation analysis was performed to identify DNAm biomarkers mediating the lead-intelligence relationship. We identified forty-three differentially methylated regions (DMRs), and two fragments (FAM50B1 and PTCHD3) significantly mediated the lead-intelligence relationship, with contribution rates of 30.36% (p = 0.010) and 60.36% (p <0.001), respectively. In addition, blood lead levels (BLLs) lower than 100 μg/L still adversely affected children's IQs and DNAm of the two fragments. Our data suggests that DNAm mediates lead-associated cognitive delay in children and blood lead reference value for school-aged children (100 μg/L) should be revised, and the candidate biomarkers can be used in related neurological diseases in future. 

AB - Although lead associated with intelligence decline in children has long been reported, studies combining intelligence determination, molecular mechanisms exploration, and biomarker screen are quite rare. In this study, based on 333 children aged 9-11, we determined the role of DNA methylation (DNAm) in the relationship of lead exposure with children's intelligence. DNAm was measured from children's blood DNA specimens, and mediation analysis was performed to identify DNAm biomarkers mediating the lead-intelligence relationship. We identified forty-three differentially methylated regions (DMRs), and two fragments (FAM50B1 and PTCHD3) significantly mediated the lead-intelligence relationship, with contribution rates of 30.36% (p = 0.010) and 60.36% (p <0.001), respectively. In addition, blood lead levels (BLLs) lower than 100 μg/L still adversely affected children's IQs and DNAm of the two fragments. Our data suggests that DNAm mediates lead-associated cognitive delay in children and blood lead reference value for school-aged children (100 μg/L) should be revised, and the candidate biomarkers can be used in related neurological diseases in future. 

KW - biomarkers

KW - blood lead

KW - children's intelligence

KW - DNA methylation

KW - FAM50B1

KW - PTCHD3

KW - Alkylation

KW - Blood

KW - DNA

KW - Methylation

KW - Blood lead level (BLLs)

KW - Contribution rate

KW - DNA Methylation

KW - Mediation analysis

KW - Molecular mechanism

KW - Neurological disease

KW - Reference values

KW - Southern China

KW - Biomarkers

U2 - 10.1021/acs.est.0c01696

DO - 10.1021/acs.est.0c01696

M3 - Journal article

VL - 55

SP - 412

EP - 422

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 1

ER -