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DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

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DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. / Brookes, Keeley Joanne; Knight, Joanne; Xu, Xunfeng et al.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , Vol. 139B, No. 1, 05.11.2005, p. 33-37.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Brookes, KJ, Knight, J, Xu, X & Asherson, P 2005, 'DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , vol. 139B, no. 1, pp. 33-37. https://doi.org/10.1002/ajmg.b.30216

APA

Brookes, K. J., Knight, J., Xu, X., & Asherson, P. (2005). DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 139B(1), 33-37. https://doi.org/10.1002/ajmg.b.30216

Vancouver

Brookes KJ, Knight J, Xu X, Asherson P. DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2005 Nov 5;139B(1):33-37. Epub 2005 Aug 4. doi: 10.1002/ajmg.b.30216

Author

Brookes, Keeley Joanne ; Knight, Joanne ; Xu, Xunfeng et al. / DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2005 ; Vol. 139B, No. 1. pp. 33-37.

Bibtex

@article{a595c22df43a44f6a99cb74a114eaff9,
title = "DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters",
abstract = "ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.",
keywords = "Attention Deficit Disorder with Hyperactivity, Cytoplasmic Vesicles, DNA, Female, Gene Frequency, Gene Pool, Genetic Markers, Genetic Predisposition to Disease, Humans, Neurotransmitter Agents, Polymorphism, Single Nucleotide, Synapses",
author = "Brookes, {Keeley Joanne} and Joanne Knight and Xunfeng Xu and Philip Asherson",
note = "(c) 2005 Wiley-Liss, Inc.",
year = "2005",
month = nov,
day = "5",
doi = "10.1002/ajmg.b.30216",
language = "English",
volume = "139B",
pages = "33--37",
journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters

AU - Brookes, Keeley Joanne

AU - Knight, Joanne

AU - Xu, Xunfeng

AU - Asherson, Philip

N1 - (c) 2005 Wiley-Liss, Inc.

PY - 2005/11/5

Y1 - 2005/11/5

N2 - ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.

AB - ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.

KW - Attention Deficit Disorder with Hyperactivity

KW - Cytoplasmic Vesicles

KW - DNA

KW - Female

KW - Gene Frequency

KW - Gene Pool

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Humans

KW - Neurotransmitter Agents

KW - Polymorphism, Single Nucleotide

KW - Synapses

U2 - 10.1002/ajmg.b.30216

DO - 10.1002/ajmg.b.30216

M3 - Journal article

C2 - 16082702

VL - 139B

SP - 33

EP - 37

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 1

ER -