Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters
AU - Brookes, Keeley Joanne
AU - Knight, Joanne
AU - Xu, Xunfeng
AU - Asherson, Philip
N1 - (c) 2005 Wiley-Liss, Inc.
PY - 2005/11/5
Y1 - 2005/11/5
N2 - ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.
AB - ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.
KW - Attention Deficit Disorder with Hyperactivity
KW - Cytoplasmic Vesicles
KW - DNA
KW - Female
KW - Gene Frequency
KW - Gene Pool
KW - Genetic Markers
KW - Genetic Predisposition to Disease
KW - Humans
KW - Neurotransmitter Agents
KW - Polymorphism, Single Nucleotide
KW - Synapses
U2 - 10.1002/ajmg.b.30216
DO - 10.1002/ajmg.b.30216
M3 - Journal article
C2 - 16082702
VL - 139B
SP - 33
EP - 37
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 1
ER -