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Domino Alkene-Isomerization–Claisen Rearrangement Strategy to Substituted Allylsilanes

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<mark>Journal publication date</mark>17/02/2012
<mark>Journal</mark>The Journal of Organic Chemistry
Issue number4
Number of pages6
Pages (from-to)2058-2063
Publication StatusPublished
Early online date10/01/12
<mark>Original language</mark>English


A one-pot isomerization–Claisen protocol has been developed for the synthesis of highly substituted allylsilanes. Monosilylated divinyl ethers can be isomerized using a cationic iridium(I) catalyst followed by a thermal Claisen rearrangement to provide the allylsilanes in excellent yields and diastereoselectivities.