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Dopamine genes and pathological gambling in discordant sib-pairs

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Dopamine genes and pathological gambling in discordant sib-pairs. / da Silva Lobo, Daniela Sabbatini; Vallada, Homero P.; Knight, Joanne et al.
In: Journal of Gambling Studies, Vol. 23, No. 4, 12.2007, p. 421-433.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

da Silva Lobo, DS, Vallada, HP, Knight, J, Martins, SS, Tavares, H, Gentil, V & Kennedy, JL 2007, 'Dopamine genes and pathological gambling in discordant sib-pairs', Journal of Gambling Studies, vol. 23, no. 4, pp. 421-433. https://doi.org/10.1007/s10899-007-9060-x

APA

da Silva Lobo, D. S., Vallada, H. P., Knight, J., Martins, S. S., Tavares, H., Gentil, V., & Kennedy, J. L. (2007). Dopamine genes and pathological gambling in discordant sib-pairs. Journal of Gambling Studies, 23(4), 421-433. https://doi.org/10.1007/s10899-007-9060-x

Vancouver

da Silva Lobo DS, Vallada HP, Knight J, Martins SS, Tavares H, Gentil V et al. Dopamine genes and pathological gambling in discordant sib-pairs. Journal of Gambling Studies. 2007 Dec;23(4):421-433. Epub 2007 Mar 30. doi: 10.1007/s10899-007-9060-x

Author

da Silva Lobo, Daniela Sabbatini ; Vallada, Homero P. ; Knight, Joanne et al. / Dopamine genes and pathological gambling in discordant sib-pairs. In: Journal of Gambling Studies. 2007 ; Vol. 23, No. 4. pp. 421-433.

Bibtex

@article{0425ce9850eb4598871f03b6f5e17910,
title = "Dopamine genes and pathological gambling in discordant sib-pairs",
abstract = "Pathological gambling (PG) is an impulse control disorder that has been considered as a behavioral addiction. Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported. In the present study, 140 sib-pairs discordant for the diagnosis of PG (70 males and 70 females on each group) were recruited through the Gambling Outpatient Unit at the Institute of Psychiatry, University of Sao Paulo and were assessed by trained psychiatrists. A family-based association design was chosen to prevent population stratification. All subjects were genotyped for dopamine receptor genes (DRD1 -800 T/C, DRD2 TaqIA RFLP, DRD3 Ser9Gly, DRD4 48bp exon III VNTR, DRD5 (CA) repeat) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Our results suggest the association of PG with DRD1 -800 T/C allele T (P = .03).",
keywords = "Adult, Brazil, Comorbidity, Disruptive, Impulse Control, and Conduct Disorders, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Middle Aged, Polymorphism, Genetic, Receptors, Dopamine, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, Dopamine D3, Receptors, Dopamine D4, Receptors, Dopamine D5, Siblings, Substance-Related Disorders",
author = "{da Silva Lobo}, {Daniela Sabbatini} and Vallada, {Homero P.} and Joanne Knight and Martins, {Silvia S.} and Hermano Tavares and Valentim Gentil and Kennedy, {James L.}",
year = "2007",
month = dec,
doi = "10.1007/s10899-007-9060-x",
language = "English",
volume = "23",
pages = "421--433",
journal = "Journal of Gambling Studies",
issn = "1050-5350",
publisher = "Springer New York",
number = "4",

}

RIS

TY - JOUR

T1 - Dopamine genes and pathological gambling in discordant sib-pairs

AU - da Silva Lobo, Daniela Sabbatini

AU - Vallada, Homero P.

AU - Knight, Joanne

AU - Martins, Silvia S.

AU - Tavares, Hermano

AU - Gentil, Valentim

AU - Kennedy, James L.

PY - 2007/12

Y1 - 2007/12

N2 - Pathological gambling (PG) is an impulse control disorder that has been considered as a behavioral addiction. Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported. In the present study, 140 sib-pairs discordant for the diagnosis of PG (70 males and 70 females on each group) were recruited through the Gambling Outpatient Unit at the Institute of Psychiatry, University of Sao Paulo and were assessed by trained psychiatrists. A family-based association design was chosen to prevent population stratification. All subjects were genotyped for dopamine receptor genes (DRD1 -800 T/C, DRD2 TaqIA RFLP, DRD3 Ser9Gly, DRD4 48bp exon III VNTR, DRD5 (CA) repeat) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Our results suggest the association of PG with DRD1 -800 T/C allele T (P = .03).

AB - Pathological gambling (PG) is an impulse control disorder that has been considered as a behavioral addiction. Recent studies have suggested the involvement of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported. In the present study, 140 sib-pairs discordant for the diagnosis of PG (70 males and 70 females on each group) were recruited through the Gambling Outpatient Unit at the Institute of Psychiatry, University of Sao Paulo and were assessed by trained psychiatrists. A family-based association design was chosen to prevent population stratification. All subjects were genotyped for dopamine receptor genes (DRD1 -800 T/C, DRD2 TaqIA RFLP, DRD3 Ser9Gly, DRD4 48bp exon III VNTR, DRD5 (CA) repeat) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Our results suggest the association of PG with DRD1 -800 T/C allele T (P = .03).

KW - Adult

KW - Brazil

KW - Comorbidity

KW - Disruptive, Impulse Control, and Conduct Disorders

KW - Dopamine Plasma Membrane Transport Proteins

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Receptors, Dopamine

KW - Receptors, Dopamine D1

KW - Receptors, Dopamine D2

KW - Receptors, Dopamine D3

KW - Receptors, Dopamine D4

KW - Receptors, Dopamine D5

KW - Siblings

KW - Substance-Related Disorders

U2 - 10.1007/s10899-007-9060-x

DO - 10.1007/s10899-007-9060-x

M3 - Journal article

C2 - 17394052

VL - 23

SP - 421

EP - 433

JO - Journal of Gambling Studies

JF - Journal of Gambling Studies

SN - 1050-5350

IS - 4

ER -