Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002
Accepted author manuscript, 1.03 MB, PDF document
Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy
AU - Hathout, Rania Mohammed Hafez Mohammed
AU - Hardy, John George
AU - Metwally, AbdelKader
AU - El-Ahmady, Sherweit
AU - Metwally, Eman
AU - Ghonim, Noha
AU - Bayoumy, Salma
AU - Erfan, Tarek
AU - Ashraf, Rosaline
AU - Fadel, Maha
AU - El-Kholy, Abdullah
N1 - This is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002
PY - 2018/7/3
Y1 - 2018/7/3
N2 - We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).
AB - We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).
KW - bioelectronics
KW - ORGANIC ELECTRONICS
KW - biomaterials
KW - cancer
KW - drug delivery
KW - regenerative medicine
U2 - 10.1016/j.jddst.2018.07.002
DO - 10.1016/j.jddst.2018.07.002
M3 - Journal article
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
ER -