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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002

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Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy

Research output: Contribution to journalJournal articlepeer-review

E-pub ahead of print

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Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. / Hathout, Rania Mohammed Hafez Mohammed; Hardy, John George; Metwally, AbdelKader; El-Ahmady, Sherweit; Metwally, Eman; Ghonim, Noha; Bayoumy, Salma; Erfan, Tarek; Ashraf, Rosaline; Fadel, Maha; El-Kholy, Abdullah.

In: Journal of Drug Delivery Science and Technology, 03.07.2018.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hathout, RMHM, Hardy, JG, Metwally, A, El-Ahmady, S, Metwally, E, Ghonim, N, Bayoumy, S, Erfan, T, Ashraf, R, Fadel, M & El-Kholy, A 2018, 'Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy', Journal of Drug Delivery Science and Technology. https://doi.org/10.1016/j.jddst.2018.07.002

APA

Hathout, R. M. H. M., Hardy, J. G., Metwally, A., El-Ahmady, S., Metwally, E., Ghonim, N., Bayoumy, S., Erfan, T., Ashraf, R., Fadel, M., & El-Kholy, A. (2018). Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. Journal of Drug Delivery Science and Technology. https://doi.org/10.1016/j.jddst.2018.07.002

Vancouver

Hathout RMHM, Hardy JG, Metwally A, El-Ahmady S, Metwally E, Ghonim N et al. Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. Journal of Drug Delivery Science and Technology. 2018 Jul 3. https://doi.org/10.1016/j.jddst.2018.07.002

Author

Hathout, Rania Mohammed Hafez Mohammed ; Hardy, John George ; Metwally, AbdelKader ; El-Ahmady, Sherweit ; Metwally, Eman ; Ghonim, Noha ; Bayoumy, Salma ; Erfan, Tarek ; Ashraf, Rosaline ; Fadel, Maha ; El-Kholy, Abdullah. / Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. In: Journal of Drug Delivery Science and Technology. 2018.

Bibtex

@article{79fd0da913e34c07969ef6b6e500e382,
title = "Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy",
abstract = "We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).",
keywords = "bioelectronics, ORGANIC ELECTRONICS, biomaterials, cancer, drug delivery, regenerative medicine",
author = "Hathout, {Rania Mohammed Hafez Mohammed} and Hardy, {John George} and AbdelKader Metwally and Sherweit El-Ahmady and Eman Metwally and Noha Ghonim and Salma Bayoumy and Tarek Erfan and Rosaline Ashraf and Maha Fadel and Abdullah El-Kholy",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002",
year = "2018",
month = jul,
day = "3",
doi = "10.1016/j.jddst.2018.07.002",
language = "English",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy

AU - Hathout, Rania Mohammed Hafez Mohammed

AU - Hardy, John George

AU - Metwally, AbdelKader

AU - El-Ahmady, Sherweit

AU - Metwally, Eman

AU - Ghonim, Noha

AU - Bayoumy, Salma

AU - Erfan, Tarek

AU - Ashraf, Rosaline

AU - Fadel, Maha

AU - El-Kholy, Abdullah

N1 - This is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002

PY - 2018/7/3

Y1 - 2018/7/3

N2 - We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).

AB - We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).

KW - bioelectronics

KW - ORGANIC ELECTRONICS

KW - biomaterials

KW - cancer

KW - drug delivery

KW - regenerative medicine

U2 - 10.1016/j.jddst.2018.07.002

DO - 10.1016/j.jddst.2018.07.002

M3 - Journal article

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

ER -