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Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies

Research output: Contribution to Journal/Magazine › Review article › peer-review

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Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies. / Sopova, Kateryna; Gatsiou, Katerina; Stellos, Konstantinos et al.
In: Current Alzheimer Research, Vol. 11, No. 1, 31.01.2014, p. 27-39.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Harvard

Sopova, K, Gatsiou, K, Stellos, K & Laske, C 2014, 'Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies', Current Alzheimer Research, vol. 11, no. 1, pp. 27-39. https://doi.org/10.2174/1567205010666131120100743

APA

Sopova, K., Gatsiou, K., Stellos, K., & Laske, C. (2014). Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies. Current Alzheimer Research, 11(1), 27-39. https://doi.org/10.2174/1567205010666131120100743

Vancouver

Sopova K, Gatsiou K, Stellos K, Laske C. Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies. Current Alzheimer Research. 2014 Jan 31;11(1):27-39. doi: 10.2174/1567205010666131120100743

Author

Sopova, Kateryna ; Gatsiou, Katerina ; Stellos, Konstantinos et al. / Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease : from pathophysiology to novel treatment strategies. In: Current Alzheimer Research. 2014 ; Vol. 11, No. 1. pp. 27-39.

Bibtex

@article{eec5bba3308f4ff99cc95e1d4ffa58b3,
title = "Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies",
abstract = "Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Growth factors have been demonstrated to act in a synergistic way in angiogenesis and neurogenesis contributing to self-healing powers of the adult human brain. A growing body of evidence demonstrates that levels of many growth factors (neurotrophins and hematopoietins) are altered in cerebrospinal fluid and peripheral blood from AD patients and in animal models of AD. The present review summarizes the role of several neurotrophic growth factors (e.g., BDNF, SCF, NGF, GDNF) and haematopoietic growth factors (e.g., G-CSF, VEGF, SDF-1) in AD. Moreover, we summarize recent studies evaluating the diagnostic and prognostic value of growth factor levels in blood and cerebrospinal fluid in patients with AD and discuss the potential role of these growth factors as a promising new therapeutic approach in AD.",
keywords = "Alzheimer Disease/drug therapy, Animals, Blood-Brain Barrier/drug effects, Brain/blood supply, Hematopoietic Cell Growth Factors/metabolism, Humans, Nerve Growth Factors/metabolism, Neurogenesis/drug effects",
author = "Kateryna Sopova and Katerina Gatsiou and Konstantinos Stellos and Christoph Laske",
year = "2014",
month = jan,
day = "31",
doi = "10.2174/1567205010666131120100743",
language = "English",
volume = "11",
pages = "27--39",
journal = "Current Alzheimer Research",
issn = "1567-2050",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

RIS

TY - JOUR

T1 - Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease

T2 - from pathophysiology to novel treatment strategies

AU - Sopova, Kateryna

AU - Gatsiou, Katerina

AU - Stellos, Konstantinos

AU - Laske, Christoph

PY - 2014/1/31

Y1 - 2014/1/31

N2 - Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Growth factors have been demonstrated to act in a synergistic way in angiogenesis and neurogenesis contributing to self-healing powers of the adult human brain. A growing body of evidence demonstrates that levels of many growth factors (neurotrophins and hematopoietins) are altered in cerebrospinal fluid and peripheral blood from AD patients and in animal models of AD. The present review summarizes the role of several neurotrophic growth factors (e.g., BDNF, SCF, NGF, GDNF) and haematopoietic growth factors (e.g., G-CSF, VEGF, SDF-1) in AD. Moreover, we summarize recent studies evaluating the diagnostic and prognostic value of growth factor levels in blood and cerebrospinal fluid in patients with AD and discuss the potential role of these growth factors as a promising new therapeutic approach in AD.

AB - Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Growth factors have been demonstrated to act in a synergistic way in angiogenesis and neurogenesis contributing to self-healing powers of the adult human brain. A growing body of evidence demonstrates that levels of many growth factors (neurotrophins and hematopoietins) are altered in cerebrospinal fluid and peripheral blood from AD patients and in animal models of AD. The present review summarizes the role of several neurotrophic growth factors (e.g., BDNF, SCF, NGF, GDNF) and haematopoietic growth factors (e.g., G-CSF, VEGF, SDF-1) in AD. Moreover, we summarize recent studies evaluating the diagnostic and prognostic value of growth factor levels in blood and cerebrospinal fluid in patients with AD and discuss the potential role of these growth factors as a promising new therapeutic approach in AD.

KW - Alzheimer Disease/drug therapy

KW - Animals

KW - Blood-Brain Barrier/drug effects

KW - Brain/blood supply

KW - Hematopoietic Cell Growth Factors/metabolism

KW - Humans

KW - Nerve Growth Factors/metabolism

KW - Neurogenesis/drug effects

U2 - 10.2174/1567205010666131120100743

DO - 10.2174/1567205010666131120100743

M3 - Review article

C2 - 24251394

VL - 11

SP - 27

EP - 39

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

IS - 1

ER -