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Effect of calcium hydroxide on mechanical strength and biological properties of bioactive glass

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • A.T. Shah
  • M. Batool
  • A.A. Chaudhry
  • F. Iqbal
  • A. Javaid
  • S. Zahid
  • K. Ilyas
  • S. bin Qasim
  • A.F. Khan
  • A.S. Khan
  • I. ur Rehman
<mark>Journal publication date</mark>1/08/2016
<mark>Journal</mark>Journal of the Mechanical Behavior of Biomedical Materials
Number of pages10
Pages (from-to)617-626
Publication StatusPublished
Early online date6/04/16
<mark>Original language</mark>English


In this manuscript for the first time calcium hydroxide (Ca(OH)2) has been used for preparation of bioactive glass (BG-2) by co-precipitation method and compared with glass prepared using calcium nitrate tetrahydrate Ca(NO3)2·4H2O (BG-1), which is a conventional source of calcium. The new source positively affected physical, biological and mechanical properties of BG-2. The glasses were characterized by Fourier transform infrared (FTIR), X-Ray Diffractometer (XRD), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis/Differential Scanning Calorimetry (TGA-DSC), BET surface area analysis and Knoop hardness. The results showed that BG-2 possessed relatively larger surface properties (100 m2 g-1 surface area) as compared to BG-1 (78 m2 g-1), spherical morphology and crystalline phases (wollastonite and apatite) after sintering at lower than conventional temperature. These properties contribute critical role in both mechanical and biological properties of glasses. The Knoop hardness measurements revealed that BG-2 possessed much better hardness (0.43±0.06 GPa at 680 °C and 2.16±0.46 GPa at 980 °C) than BG-1 (0.24±0.01 at 680 °C and 0.57±0.07GPA at 980 °C) under same conditions. Alamar blue Assay and confocal microscopy revealed that BG-2 exhibited better attachment and proliferation of MG63 cells. Based on the improved biological properties of BG-2 as a consequent of novel calcium source selection, BG-2 is proposed as a bioactive ceramic for hard tissue repair and regeneration applications.