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Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures

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Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures. / Podder, Soumik; Chanda, Dipak; Mukhopadhyay, Anoop Kumar; De, Arnab; Das, Bhaskar; Samanta, Amalesh; Hardy, John George; Ghosh, Chandan Kumar.

In: Inorganic Chemistry, Vol. 57, No. 20, 15.10.2018, p. 12727-12739.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Podder, S, Chanda, D, Mukhopadhyay, AK, De, A, Das, B, Samanta, A, Hardy, JG & Ghosh, CK 2018, 'Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures', Inorganic Chemistry, vol. 57, no. 20, pp. 12727-12739. https://doi.org/10.1021/acs.inorgchem.8b01938

APA

Podder, S., Chanda, D., Mukhopadhyay, A. K., De, A., Das, B., Samanta, A., Hardy, J. G., & Ghosh, C. K. (2018). Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures. Inorganic Chemistry, 57(20), 12727-12739. https://doi.org/10.1021/acs.inorgchem.8b01938

Vancouver

Podder S, Chanda D, Mukhopadhyay AK, De A, Das B, Samanta A et al. Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures. Inorganic Chemistry. 2018 Oct 15;57(20):12727-12739. https://doi.org/10.1021/acs.inorgchem.8b01938

Author

Podder, Soumik ; Chanda, Dipak ; Mukhopadhyay, Anoop Kumar ; De, Arnab ; Das, Bhaskar ; Samanta, Amalesh ; Hardy, John George ; Ghosh, Chandan Kumar. / Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures. In: Inorganic Chemistry. 2018 ; Vol. 57, No. 20. pp. 12727-12739.

Bibtex

@article{721bf351cbe94d49a89bfd619a7cf826,
title = "Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures",
abstract = "The toxicity of nanomaterials can sometimes be attributed to photogenerated reactive oxygen species (ROS), but these ROS can also be scavenged by nanomaterials, yielding opportunities for crossover between the properties. The morphology of nanomaterials also influences such features due to defect-induced properties. Here we report morphology-induced crossover between pro-oxidant activity (ROS generation) and antioxidant activity (ROS scavenging) of MgO. To study this process in detail, we prepared three different nanostructures of MgO (nanoparticles, nanoplates, and nanorods) and characterized them by HRTEM. These three nanostructures effectively generate superoxide anions (O2 •-) and hydroxyl radicals (•OH) at higher concentrations (>500 μg/mL) but scavenge O2 •- at lower concentrations (40 μg/mL) with successful crossover at 200 μg/mL. Nanorods of MgO generate the highest levels of O2 •-, whereas nanoparticles scavenge O2 •- to the highest extent (60%). Photoluminescence studies reveal that such crossover is based on the suppression of F2+ and the evolution of F+, F2 +, and F2 3+ defect centers. The evolution of these defect centers reflects the antibacterial activity of MgO nanostructures which is initiated at 200 μg/mL against Gram-positive S. aureus ATCC 29737 and among different bacterial strains including Gram-positive B. subtilis ATCC 6633 and M. luteus ATCC 10240 and Gram-negative E. coli ATCC K88 and K. pneumoniae ATCC 10031. Nanoparticles exhibited the highest antibacterial (92%) and antibiofilm activity (17%) against B. subtilis ATCC 6633 in the dark. Interestingly, the nitrogen-centered free radical DPPH is scavenged (100%) by nanoplates due to its large surface area (342.2 m2/g) and the presence of the F2 + defect state. The concentration-dependent interaction with an antioxidant defense system (ascorbic acid (AA)) highlights nanoparticles as potent scavengers of O2 •- in the dark. Thus, our findings establish guidelines for the selection of MgO nanostructures for diverse therapeutic applications.",
keywords = "nanoparticles, materials science, inorganic chemistry, biomedical engineering, pharmacy, antimicrobial",
author = "Soumik Podder and Dipak Chanda and Mukhopadhyay, {Anoop Kumar} and Arnab De and Bhaskar Das and Amalesh Samanta and Hardy, {John George} and Ghosh, {Chandan Kumar}",
year = "2018",
month = oct,
day = "15",
doi = "10.1021/acs.inorgchem.8b01938",
language = "English",
volume = "57",
pages = "12727--12739",
journal = "Inorganic Chemistry",
issn = "0020-1669",
publisher = "American Chemical Society",
number = "20",

}

RIS

TY - JOUR

T1 - Effect of Morphology and Concentration on Crossover between Antioxidant and Pro-oxidant Activity of MgO Nanostructures

AU - Podder, Soumik

AU - Chanda, Dipak

AU - Mukhopadhyay, Anoop Kumar

AU - De, Arnab

AU - Das, Bhaskar

AU - Samanta, Amalesh

AU - Hardy, John George

AU - Ghosh, Chandan Kumar

PY - 2018/10/15

Y1 - 2018/10/15

N2 - The toxicity of nanomaterials can sometimes be attributed to photogenerated reactive oxygen species (ROS), but these ROS can also be scavenged by nanomaterials, yielding opportunities for crossover between the properties. The morphology of nanomaterials also influences such features due to defect-induced properties. Here we report morphology-induced crossover between pro-oxidant activity (ROS generation) and antioxidant activity (ROS scavenging) of MgO. To study this process in detail, we prepared three different nanostructures of MgO (nanoparticles, nanoplates, and nanorods) and characterized them by HRTEM. These three nanostructures effectively generate superoxide anions (O2 •-) and hydroxyl radicals (•OH) at higher concentrations (>500 μg/mL) but scavenge O2 •- at lower concentrations (40 μg/mL) with successful crossover at 200 μg/mL. Nanorods of MgO generate the highest levels of O2 •-, whereas nanoparticles scavenge O2 •- to the highest extent (60%). Photoluminescence studies reveal that such crossover is based on the suppression of F2+ and the evolution of F+, F2 +, and F2 3+ defect centers. The evolution of these defect centers reflects the antibacterial activity of MgO nanostructures which is initiated at 200 μg/mL against Gram-positive S. aureus ATCC 29737 and among different bacterial strains including Gram-positive B. subtilis ATCC 6633 and M. luteus ATCC 10240 and Gram-negative E. coli ATCC K88 and K. pneumoniae ATCC 10031. Nanoparticles exhibited the highest antibacterial (92%) and antibiofilm activity (17%) against B. subtilis ATCC 6633 in the dark. Interestingly, the nitrogen-centered free radical DPPH is scavenged (100%) by nanoplates due to its large surface area (342.2 m2/g) and the presence of the F2 + defect state. The concentration-dependent interaction with an antioxidant defense system (ascorbic acid (AA)) highlights nanoparticles as potent scavengers of O2 •- in the dark. Thus, our findings establish guidelines for the selection of MgO nanostructures for diverse therapeutic applications.

AB - The toxicity of nanomaterials can sometimes be attributed to photogenerated reactive oxygen species (ROS), but these ROS can also be scavenged by nanomaterials, yielding opportunities for crossover between the properties. The morphology of nanomaterials also influences such features due to defect-induced properties. Here we report morphology-induced crossover between pro-oxidant activity (ROS generation) and antioxidant activity (ROS scavenging) of MgO. To study this process in detail, we prepared three different nanostructures of MgO (nanoparticles, nanoplates, and nanorods) and characterized them by HRTEM. These three nanostructures effectively generate superoxide anions (O2 •-) and hydroxyl radicals (•OH) at higher concentrations (>500 μg/mL) but scavenge O2 •- at lower concentrations (40 μg/mL) with successful crossover at 200 μg/mL. Nanorods of MgO generate the highest levels of O2 •-, whereas nanoparticles scavenge O2 •- to the highest extent (60%). Photoluminescence studies reveal that such crossover is based on the suppression of F2+ and the evolution of F+, F2 +, and F2 3+ defect centers. The evolution of these defect centers reflects the antibacterial activity of MgO nanostructures which is initiated at 200 μg/mL against Gram-positive S. aureus ATCC 29737 and among different bacterial strains including Gram-positive B. subtilis ATCC 6633 and M. luteus ATCC 10240 and Gram-negative E. coli ATCC K88 and K. pneumoniae ATCC 10031. Nanoparticles exhibited the highest antibacterial (92%) and antibiofilm activity (17%) against B. subtilis ATCC 6633 in the dark. Interestingly, the nitrogen-centered free radical DPPH is scavenged (100%) by nanoplates due to its large surface area (342.2 m2/g) and the presence of the F2 + defect state. The concentration-dependent interaction with an antioxidant defense system (ascorbic acid (AA)) highlights nanoparticles as potent scavengers of O2 •- in the dark. Thus, our findings establish guidelines for the selection of MgO nanostructures for diverse therapeutic applications.

KW - nanoparticles

KW - materials science

KW - inorganic chemistry

KW - biomedical engineering

KW - pharmacy

KW - antimicrobial

U2 - 10.1021/acs.inorgchem.8b01938

DO - 10.1021/acs.inorgchem.8b01938

M3 - Journal article

C2 - 30281293

AN - SCOPUS:85054645642

VL - 57

SP - 12727

EP - 12739

JO - Inorganic Chemistry

JF - Inorganic Chemistry

SN - 0020-1669

IS - 20

ER -