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Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells

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Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. / Quincozes-Santos, André; Abib, Renata Torres; Leite, Marina Concli et al.
In: Molecular and Cellular Biochemistry, Vol. 314, No. 1-2, 59, 31.07.2008, p. 59-63.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Quincozes-Santos, A, Abib, RT, Leite, MC, Bobermin, D, Bambini-Junior, V, Gonçalves, C-A, Riesgo, R & Gottfried, C 2008, 'Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells', Molecular and Cellular Biochemistry, vol. 314, no. 1-2, 59, pp. 59-63. https://doi.org/10.1007/s11010-008-9765-x

APA

Quincozes-Santos, A., Abib, R. T., Leite, M. C., Bobermin, D., Bambini-Junior, V., Gonçalves, C.-A., Riesgo, R., & Gottfried, C. (2008). Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. Molecular and Cellular Biochemistry, 314(1-2), 59-63. Article 59. https://doi.org/10.1007/s11010-008-9765-x

Vancouver

Quincozes-Santos A, Abib RT, Leite MC, Bobermin D, Bambini-Junior V, Gonçalves CA et al. Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. Molecular and Cellular Biochemistry. 2008 Jul 31;314(1-2):59-63. 59. Epub 2008 Apr 18. doi: 10.1007/s11010-008-9765-x

Author

Quincozes-Santos, André ; Abib, Renata Torres ; Leite, Marina Concli et al. / Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. In: Molecular and Cellular Biochemistry. 2008 ; Vol. 314, No. 1-2. pp. 59-63.

Bibtex

@article{69b4aaf1b1184cc6961e4a02ac9b08d5,
title = "Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells",
abstract = "We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.",
keywords = "Animals, Antipsychotic Agents/pharmacology, Astrocytes/cytology, Cell Lineage/drug effects, Cell Membrane Permeability/drug effects, Cell Shape/drug effects, Cell Survival/drug effects, Cells, Cultured, Drug Evaluation, Preclinical, Nerve Growth Factors/metabolism, Rats, Risperidone/pharmacology, S100 Calcium Binding Protein beta Subunit, S100 Proteins/metabolism",
author = "Andr{\'e} Quincozes-Santos and Abib, {Renata Torres} and Leite, {Marina Concli} and Daiane Bobermin and Victorio Bambini-Junior and Carlos-Alberto Gon{\c c}alves and Rudimar Riesgo and Carmem Gottfried",
year = "2008",
month = jul,
day = "31",
doi = "10.1007/s11010-008-9765-x",
language = "English",
volume = "314",
pages = "59--63",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "1-2",

}

RIS

TY - JOUR

T1 - Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells

AU - Quincozes-Santos, André

AU - Abib, Renata Torres

AU - Leite, Marina Concli

AU - Bobermin, Daiane

AU - Bambini-Junior, Victorio

AU - Gonçalves, Carlos-Alberto

AU - Riesgo, Rudimar

AU - Gottfried, Carmem

PY - 2008/7/31

Y1 - 2008/7/31

N2 - We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.

AB - We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.

KW - Animals

KW - Antipsychotic Agents/pharmacology

KW - Astrocytes/cytology

KW - Cell Lineage/drug effects

KW - Cell Membrane Permeability/drug effects

KW - Cell Shape/drug effects

KW - Cell Survival/drug effects

KW - Cells, Cultured

KW - Drug Evaluation, Preclinical

KW - Nerve Growth Factors/metabolism

KW - Rats

KW - Risperidone/pharmacology

KW - S100 Calcium Binding Protein beta Subunit

KW - S100 Proteins/metabolism

U2 - 10.1007/s11010-008-9765-x

DO - 10.1007/s11010-008-9765-x

M3 - Journal article

C2 - 18421423

VL - 314

SP - 59

EP - 63

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

M1 - 59

ER -