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Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials

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Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials. / Kim, Semin; Jeong, Jin-Oh; Lee, Sanghun; Park, Jong-Seok; Gwon, Hui-Jeong; Jeong, Sung In; Hardy, John George; Lim, Youn-Mook; Lee, Jae.

In: Scientific Reports, Vol. 8, 3721, 27.02.2018.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kim, S, Jeong, J-O, Lee, S, Park, J-S, Gwon, H-J, Jeong, SI, Hardy, JG, Lim, Y-M & Lee, J 2018, 'Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials', Scientific Reports, vol. 8, 3721. https://doi.org/10.1038/s41598-018-22066-6

APA

Kim, S., Jeong, J-O., Lee, S., Park, J-S., Gwon, H-J., Jeong, S. I., Hardy, J. G., Lim, Y-M., & Lee, J. (2018). Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials. Scientific Reports, 8, [3721]. https://doi.org/10.1038/s41598-018-22066-6

Vancouver

Kim S, Jeong J-O, Lee S, Park J-S, Gwon H-J, Jeong SI et al. Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials. Scientific Reports. 2018 Feb 27;8. 3721. https://doi.org/10.1038/s41598-018-22066-6

Author

Kim, Semin ; Jeong, Jin-Oh ; Lee, Sanghun ; Park, Jong-Seok ; Gwon, Hui-Jeong ; Jeong, Sung In ; Hardy, John George ; Lim, Youn-Mook ; Lee, Jae. / Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials. In: Scientific Reports. 2018 ; Vol. 8.

Bibtex

@article{b4e76796d0184c0e9f10852dd222a2f8,
title = "Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials",
abstract = "Conductive polymers, including polypyrrole (PPy), have been extensively explored to fabricate electrically conductive biomaterials for bioelectrodes and tissue engineering scaffolds. For their in vivo uses, a sterilization method without severe impairment of original material properties and performance is necessary. Gamma-ray radiation has been commonly applied for sterilization of medical products because of its simple and uniform sterilization without heat generation. Herein we describe the first study on gamma-ray sterilization of PPy bioelectrodes and its effects on their characteristics. We irradiated PPy bioelectrodes with different doses (0–75 kGy) of gamma-rays. Gamma-ray irradiation of the PPy (γ-PPy) increased the oxygenation and hydrophilicity of the surfaces. Interestingly, gamma-ray irradiation did not alter the electrical impedances and conductivities of the PPy substrates. Additionally, γ-PPy prepared with various dopants (e.g., para-toluene sulfonate, polystyrene sulfonate, and chlorine) showed the electrochemical properties similar to the non-irradiated control. Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed cytocompatibility similar to untreated control PPy, indicating no substantial alteration of cytocompatibility. In conclusion, gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.",
keywords = "Biomaterials, Biomedical materials",
author = "Semin Kim and Jin-Oh Jeong and Sanghun Lee and Jong-Seok Park and Hui-Jeong Gwon and Jeong, {Sung In} and Hardy, {John George} and Youn-Mook Lim and Jae Lee",
year = "2018",
month = feb,
day = "27",
doi = "10.1038/s41598-018-22066-6",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials

AU - Kim, Semin

AU - Jeong, Jin-Oh

AU - Lee, Sanghun

AU - Park, Jong-Seok

AU - Gwon, Hui-Jeong

AU - Jeong, Sung In

AU - Hardy, John George

AU - Lim, Youn-Mook

AU - Lee, Jae

PY - 2018/2/27

Y1 - 2018/2/27

N2 - Conductive polymers, including polypyrrole (PPy), have been extensively explored to fabricate electrically conductive biomaterials for bioelectrodes and tissue engineering scaffolds. For their in vivo uses, a sterilization method without severe impairment of original material properties and performance is necessary. Gamma-ray radiation has been commonly applied for sterilization of medical products because of its simple and uniform sterilization without heat generation. Herein we describe the first study on gamma-ray sterilization of PPy bioelectrodes and its effects on their characteristics. We irradiated PPy bioelectrodes with different doses (0–75 kGy) of gamma-rays. Gamma-ray irradiation of the PPy (γ-PPy) increased the oxygenation and hydrophilicity of the surfaces. Interestingly, gamma-ray irradiation did not alter the electrical impedances and conductivities of the PPy substrates. Additionally, γ-PPy prepared with various dopants (e.g., para-toluene sulfonate, polystyrene sulfonate, and chlorine) showed the electrochemical properties similar to the non-irradiated control. Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed cytocompatibility similar to untreated control PPy, indicating no substantial alteration of cytocompatibility. In conclusion, gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.

AB - Conductive polymers, including polypyrrole (PPy), have been extensively explored to fabricate electrically conductive biomaterials for bioelectrodes and tissue engineering scaffolds. For their in vivo uses, a sterilization method without severe impairment of original material properties and performance is necessary. Gamma-ray radiation has been commonly applied for sterilization of medical products because of its simple and uniform sterilization without heat generation. Herein we describe the first study on gamma-ray sterilization of PPy bioelectrodes and its effects on their characteristics. We irradiated PPy bioelectrodes with different doses (0–75 kGy) of gamma-rays. Gamma-ray irradiation of the PPy (γ-PPy) increased the oxygenation and hydrophilicity of the surfaces. Interestingly, gamma-ray irradiation did not alter the electrical impedances and conductivities of the PPy substrates. Additionally, γ-PPy prepared with various dopants (e.g., para-toluene sulfonate, polystyrene sulfonate, and chlorine) showed the electrochemical properties similar to the non-irradiated control. Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed cytocompatibility similar to untreated control PPy, indicating no substantial alteration of cytocompatibility. In conclusion, gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.

KW - Biomaterials

KW - Biomedical materials

U2 - 10.1038/s41598-018-22066-6

DO - 10.1038/s41598-018-22066-6

M3 - Journal article

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 3721

ER -