TY - JOUR

T1 - Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions

AU - Quincozes-Santos, André

AU - Bobermin, Larissa Daniele

AU - Tonial, Rafaela Pestana Leques

AU - Bambini-Junior, Victorio

AU - Riesgo, Rudimar

AU - Gottfried, Carmem

PY - 2010/9/30

Y1 - 2010/9/30

N2 - Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 μM) regarding different aspects such as glutamate uptake, glutamine synthetase (GS) activity, glutathione (GSH) content, and intracellular reactive oxygen species (ROS) production in C6 astroglial cells. Risperidone significantly increased glutamate uptake (up to 27%), GS activity (14%), and GSH content (up to 17%). In contrast, haloperidol was not able to change any of these glial functions. However, at concentration of 10 μM, haloperidol increased (12%) ROS production. Our data contribute to the clarification of different hypothesis concerning the putative neural responses after stimulus with different antipsychotics, and may establish important insights about how brain rewiring could be enhanced.

AB - Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 μM) regarding different aspects such as glutamate uptake, glutamine synthetase (GS) activity, glutathione (GSH) content, and intracellular reactive oxygen species (ROS) production in C6 astroglial cells. Risperidone significantly increased glutamate uptake (up to 27%), GS activity (14%), and GSH content (up to 17%). In contrast, haloperidol was not able to change any of these glial functions. However, at concentration of 10 μM, haloperidol increased (12%) ROS production. Our data contribute to the clarification of different hypothesis concerning the putative neural responses after stimulus with different antipsychotics, and may establish important insights about how brain rewiring could be enhanced.

KW - Animals

KW - Antipsychotic Agents/pharmacology

KW - Astrocytes/drug effects

KW - Brain Chemistry/drug effects

KW - Cell Line

KW - Glutamate-Ammonia Ligase/analysis

KW - Glutamic Acid/analysis

KW - Glutathione/analysis

KW - Haloperidol/pharmacology

KW - Humans

KW - Reactive Oxygen Species/analysis

KW - Risperidone/pharmacology

KW - Schizophrenia/drug therapy

U2 - 10.1007/s00406-009-0095-0

DO - 10.1007/s00406-009-0095-0

M3 - Journal article

C2 - 20041330

VL - 260

SP - 475

EP - 481

JO - European Archives of Psychiatry and Clinial Neuroscience

JF - European Archives of Psychiatry and Clinial Neuroscience

SN - 0940-1334

IS - 6

ER -