Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.8b11546
Accepted author manuscript, 1.37 MB, PDF document
Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Electrically Conductive Polydopamine–Polypyrrole as High Performance Biomaterials for Cell Stimulation in Vitro and Electrical Signal Recording in Vivo
AU - Kim, Semin
AU - Jang, Lindy
AU - Jang, Minsu
AU - Lee, Sanghun
AU - Hardy, John George
AU - Lee, Jae
N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.8b11546
PY - 2018/10/3
Y1 - 2018/10/3
N2 - Conductive polymers (CPs) such as polypyrrole (PPY) are emerging biomaterials for use as scaffolds and bioelectrodes which interact with biological systems electrically. Still, more electrically conductive and biologically interactive CPs are required to develop high performance biomaterials and medical devices. In this study, in situ electrochemical copolymerization of polydopamine (PDA) and PPY were performed for electrode modification. Their material and biological properties were characterized using multiple techniques. The electrical properties of electrodes coated with PDA/PPY were superior to electrodes coated with PPY alone. The growth and differentiation of C2C12 myoblasts and PC12 neuronal cells on PDA/PPY was enhanced compared to PPY. Electrical stimulation of PC12 cells on PDA/PPY further promoted neuritogenesis. In vivo electromyography signal measurements demonstrated more sensitive signals from tibia muscles when using PDA/PPY-coated electrodes than bare or PPY-coated electrodes, revealing PDA/PPY to be a high-performance biomaterial with potential for various biomedical applications.
AB - Conductive polymers (CPs) such as polypyrrole (PPY) are emerging biomaterials for use as scaffolds and bioelectrodes which interact with biological systems electrically. Still, more electrically conductive and biologically interactive CPs are required to develop high performance biomaterials and medical devices. In this study, in situ electrochemical copolymerization of polydopamine (PDA) and PPY were performed for electrode modification. Their material and biological properties were characterized using multiple techniques. The electrical properties of electrodes coated with PDA/PPY were superior to electrodes coated with PPY alone. The growth and differentiation of C2C12 myoblasts and PC12 neuronal cells on PDA/PPY was enhanced compared to PPY. Electrical stimulation of PC12 cells on PDA/PPY further promoted neuritogenesis. In vivo electromyography signal measurements demonstrated more sensitive signals from tibia muscles when using PDA/PPY-coated electrodes than bare or PPY-coated electrodes, revealing PDA/PPY to be a high-performance biomaterial with potential for various biomedical applications.
KW - conducting polymers
KW - electroactive polymers
KW - biomaterials
KW - Biomedical Engineering
KW - tissue engineering
KW - neural electrodes
KW - bioelectronics
KW - materials science
U2 - 10.1021/acsami.8b11546
DO - 10.1021/acsami.8b11546
M3 - Journal article
VL - 10
SP - 33032
EP - 33042
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
SN - 1944-8244
IS - 39
ER -