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Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering

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Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering. / Hardy, John G.; Cornelison, R. Chase; Sukhavasi, Rushi C.; Saballos, Richard J.; Vu, Philip; Kaplan, David L.; Schmidt, Christine E.

In: Bioengineering, Vol. 2, No. 1, 14.01.2015, p. 15-34.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hardy, JG, Cornelison, RC, Sukhavasi, RC, Saballos, RJ, Vu, P, Kaplan, DL & Schmidt, CE 2015, 'Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering', Bioengineering, vol. 2, no. 1, pp. 15-34. https://doi.org/10.3390/bioengineering2010015

APA

Hardy, J. G., Cornelison, R. C., Sukhavasi, R. C., Saballos, R. J., Vu, P., Kaplan, D. L., & Schmidt, C. E. (2015). Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering. Bioengineering, 2(1), 15-34. https://doi.org/10.3390/bioengineering2010015

Vancouver

Hardy JG, Cornelison RC, Sukhavasi RC, Saballos RJ, Vu P, Kaplan DL et al. Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering. Bioengineering. 2015 Jan 14;2(1):15-34. https://doi.org/10.3390/bioengineering2010015

Author

Hardy, John G. ; Cornelison, R. Chase ; Sukhavasi, Rushi C. ; Saballos, Richard J. ; Vu, Philip ; Kaplan, David L. ; Schmidt, Christine E. / Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering. In: Bioengineering. 2015 ; Vol. 2, No. 1. pp. 15-34.

Bibtex

@article{5f8189d9ec6c4f40aff7a5f1cf86f77b,
title = "Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering",
abstract = "Tissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF).",
keywords = "BIOMATERIALS, POROSITY, tissue scaffold, tissue engineering, Regenerative Medicine, Chemistry(all), Biomaterials, electroactive polymers, microfabrication, nerve guide, peripheral nerve, plastic electronics, topography",
author = "Hardy, {John G.} and Cornelison, {R. Chase} and Sukhavasi, {Rushi C.} and Saballos, {Richard J.} and Philip Vu and Kaplan, {David L.} and Schmidt, {Christine E.}",
year = "2015",
month = jan,
day = "14",
doi = "10.3390/bioengineering2010015",
language = "English",
volume = "2",
pages = "15--34",
journal = "Bioengineering",
issn = "2306-5354",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering

AU - Hardy, John G.

AU - Cornelison, R. Chase

AU - Sukhavasi, Rushi C.

AU - Saballos, Richard J.

AU - Vu, Philip

AU - Kaplan, David L.

AU - Schmidt, Christine E.

PY - 2015/1/14

Y1 - 2015/1/14

N2 - Tissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF).

AB - Tissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF).

KW - BIOMATERIALS

KW - POROSITY

KW - tissue scaffold

KW - tissue engineering

KW - Regenerative Medicine

KW - Chemistry(all)

KW - Biomaterials

KW - electroactive polymers

KW - microfabrication

KW - nerve guide

KW - peripheral nerve

KW - plastic electronics

KW - topography

U2 - 10.3390/bioengineering2010015

DO - 10.3390/bioengineering2010015

M3 - Journal article

VL - 2

SP - 15

EP - 34

JO - Bioengineering

JF - Bioengineering

SN - 2306-5354

IS - 1

ER -