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Engineered spider silk protein-based composites for drug delivery

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Engineered spider silk protein-based composites for drug delivery. / Hardy, John; Leal-Egana, Aldo; Scheibel, Thomas R.
In: Macromolecular Bioscience , Vol. 13, No. 10, 10.2013, p. 1431-1437.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hardy, J, Leal-Egana, A & Scheibel, TR 2013, 'Engineered spider silk protein-based composites for drug delivery', Macromolecular Bioscience , vol. 13, no. 10, pp. 1431-1437. https://doi.org/10.1002/mabi.201300233

APA

Hardy, J., Leal-Egana, A., & Scheibel, T. R. (2013). Engineered spider silk protein-based composites for drug delivery. Macromolecular Bioscience , 13(10), 1431-1437. https://doi.org/10.1002/mabi.201300233

Vancouver

Hardy J, Leal-Egana A, Scheibel TR. Engineered spider silk protein-based composites for drug delivery. Macromolecular Bioscience . 2013 Oct;13(10):1431-1437. Epub 2013 Jul 23. doi: 10.1002/mabi.201300233

Author

Hardy, John ; Leal-Egana, Aldo ; Scheibel, Thomas R. / Engineered spider silk protein-based composites for drug delivery. In: Macromolecular Bioscience . 2013 ; Vol. 13, No. 10. pp. 1431-1437.

Bibtex

@article{8a1c128036784148882c6ef90c371f3d,
title = "Engineered spider silk protein-based composites for drug delivery",
abstract = "Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.",
keywords = "biodegradable biomaterials, coatings, composites, drug delivery, IN-VITRO, BIOMEDICAL APPLICATIONS, BIODEGRADABLE POLYMERS, L-ALANINE, BIOMATERIALS, POLYURETHANES, SURFACES, VIVO, ADHESION, FIBROIN, Biomaterials, Chemistry(all)",
author = "John Hardy and Aldo Leal-Egana and Scheibel, {Thomas R.}",
year = "2013",
month = oct,
doi = "10.1002/mabi.201300233",
language = "English",
volume = "13",
pages = "1431--1437",
journal = "Macromolecular Bioscience ",
issn = "1616-5187",
publisher = "Wiley-VCH Verlag",
number = "10",

}

RIS

TY - JOUR

T1 - Engineered spider silk protein-based composites for drug delivery

AU - Hardy, John

AU - Leal-Egana, Aldo

AU - Scheibel, Thomas R.

PY - 2013/10

Y1 - 2013/10

N2 - Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

AB - Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.

KW - biodegradable biomaterials

KW - coatings

KW - composites

KW - drug delivery

KW - IN-VITRO

KW - BIOMEDICAL APPLICATIONS

KW - BIODEGRADABLE POLYMERS

KW - L-ALANINE

KW - BIOMATERIALS

KW - POLYURETHANES

KW - SURFACES

KW - VIVO

KW - ADHESION

KW - FIBROIN

KW - Biomaterials

KW - Chemistry(all)

U2 - 10.1002/mabi.201300233

DO - 10.1002/mabi.201300233

M3 - Journal article

VL - 13

SP - 1431

EP - 1437

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

IS - 10

ER -