Home > Research > Publications & Outputs > Enhanced meta-analysis and replication studies ...

Research

Associated organisational unit

Links

Text available via DOI:

View graph of relations

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. / Tsoi, Lam C.; Spain, Sarah L.; Ellinghaus, Eva et al.
In: Nature Communications, Vol. 6, 7001, 05.05.2015.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Tsoi, LC, Spain, SL, Ellinghaus, E, Stuart, PE, Capon, F, Knight, J, Tejasvi, T, Kang, HM, Allen, MH, Lambert, S, Stoll, SW, Weidinger, S, Gudjonsson, JE, Koks, S, Kingo, K, Esko, T, Das, S, Metspalu, A, Weichenthal, M, Enerback, C, Krueger, GG, Voorhees, JJ, Chandran, V, Rosen, CF, Rahman, P, Gladman, DD, Reis, A, Nair, RP, Franke, A, Barker, JNWN, Abecasis, GR, Trembath, RC & Elder, JT 2015, 'Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci', Nature Communications, vol. 6, 7001. https://doi.org/10.1038/ncomms8001

APA

Tsoi, L. C., Spain, S. L., Ellinghaus, E., Stuart, P. E., Capon, F., Knight, J., Tejasvi, T., Kang, H. M., Allen, M. H., Lambert, S., Stoll, S. W., Weidinger, S., Gudjonsson, J. E., Koks, S., Kingo, K., Esko, T., Das, S., Metspalu, A., Weichenthal, M., ... Elder, J. T. (2015). Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nature Communications, 6, Article 7001. https://doi.org/10.1038/ncomms8001

Vancouver

Tsoi LC, Spain SL, Ellinghaus E, Stuart PE, Capon F, Knight J et al. Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nature Communications. 2015 May 5;6:7001. doi: 10.1038/ncomms8001

Author

Tsoi, Lam C. ; Spain, Sarah L. ; Ellinghaus, Eva et al. / Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. In: Nature Communications. 2015 ; Vol. 6.

Bibtex

@article{6e997261b6564ba0b5333105972be23d,
title = "Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci",
abstract = "Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 × 10(-8)). The newly identified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residing near PLCL2 (3p24.3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong candidate genes. These results further integrate the genetics and immunology of psoriasis, suggesting new avenues for functional analysis and improved therapies.",
author = "Tsoi, {Lam C.} and Spain, {Sarah L.} and Eva Ellinghaus and Stuart, {Philip E.} and Francesca Capon and Joanne Knight and Trilokraj Tejasvi and Kang, {Hyun M.} and Allen, {Michael H.} and Sylviane Lambert and Stoll, {Stefan W.} and Stephan Weidinger and Gudjonsson, {Johann E.} and Sulev Koks and K{\"u}lli Kingo and Tonu Esko and Sayantan Das and Andres Metspalu and Michael Weichenthal and Charlotta Enerback and Krueger, {Gerald G.} and Voorhees, {John J.} and Vinod Chandran and Rosen, {Cheryl F.} and Proton Rahman and Gladman, {Dafna D.} and Andre Reis and Nair, {Rajan P.} and Andre Franke and Barker, {Jonathan N. W. N.} and Abecasis, {Goncalo R.} and Trembath, {Richard C.} and Elder, {James T.}",
year = "2015",
month = may,
day = "5",
doi = "10.1038/ncomms8001",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

AU - Tsoi, Lam C.

AU - Spain, Sarah L.

AU - Ellinghaus, Eva

AU - Stuart, Philip E.

AU - Capon, Francesca

AU - Knight, Joanne

AU - Tejasvi, Trilokraj

AU - Kang, Hyun M.

AU - Allen, Michael H.

AU - Lambert, Sylviane

AU - Stoll, Stefan W.

AU - Weidinger, Stephan

AU - Gudjonsson, Johann E.

AU - Koks, Sulev

AU - Kingo, Külli

AU - Esko, Tonu

AU - Das, Sayantan

AU - Metspalu, Andres

AU - Weichenthal, Michael

AU - Enerback, Charlotta

AU - Krueger, Gerald G.

AU - Voorhees, John J.

AU - Chandran, Vinod

AU - Rosen, Cheryl F.

AU - Rahman, Proton

AU - Gladman, Dafna D.

AU - Reis, Andre

AU - Nair, Rajan P.

AU - Franke, Andre

AU - Barker, Jonathan N. W. N.

AU - Abecasis, Goncalo R.

AU - Trembath, Richard C.

AU - Elder, James T.

PY - 2015/5/5

Y1 - 2015/5/5

N2 - Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 × 10(-8)). The newly identified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residing near PLCL2 (3p24.3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong candidate genes. These results further integrate the genetics and immunology of psoriasis, suggesting new avenues for functional analysis and improved therapies.

AB - Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 × 10(-8)). The newly identified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residing near PLCL2 (3p24.3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong candidate genes. These results further integrate the genetics and immunology of psoriasis, suggesting new avenues for functional analysis and improved therapies.

U2 - 10.1038/ncomms8001

DO - 10.1038/ncomms8001

M3 - Journal article

C2 - 25939698

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7001

ER -