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    Rights statement: This is the author’s version of a work that was accepted for publication in Journal of Hazardous Materials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Hazardous Materials, 419, 2021 DOI: 10.1016/j.jhazmat.2021.126471

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Evaluating the simulated toxicities of metal mixtures and hydrocarbons using the alkane degrading bioreporter Acinetobacter baylyi ADPWH_recA

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Evaluating the simulated toxicities of metal mixtures and hydrocarbons using the alkane degrading bioreporter Acinetobacter baylyi ADPWH_recA. / Li, H.; Yang, Y.; Zhang, D. et al.

In: Journal of Hazardous Materials, Vol. 419, 126471, 05.10.2021.

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Li H, Yang Y, Zhang D, Li Y, Zhang H, Luo J et al. Evaluating the simulated toxicities of metal mixtures and hydrocarbons using the alkane degrading bioreporter Acinetobacter baylyi ADPWH_recA. Journal of Hazardous Materials. 2021 Oct 5;419:126471. Epub 2021 Jun 25. doi: 10.1016/j.jhazmat.2021.126471

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@article{1b5bf4f14df94cda8eff40f1ab63aaf8,
title = "Evaluating the simulated toxicities of metal mixtures and hydrocarbons using the alkane degrading bioreporter Acinetobacter baylyi ADPWH_recA",
abstract = "Oil spillages lead to the formation of hydrocarbon and metal mixtures possessing effects on alkane-degrading bacteria that are responsible for the bioremediation of oil-contaminated soils and waters. Studies of bacterial responses to the mixture of petroleum and metal can inform appropriate strategies for bioremediation. We employed a luminescent bioreporter Acinetobacter baylyi ADPWH_recA with alkane degradation capability to evaluate the combined effects from heavy metals (Cd, Pb and Cu) and alkanes (dodecane, tetradecane, hexadecane and octadecane). Bioluminescent ratios of ADPWH_recA in single Cd or Pb treatments ranged from 0.25 to 1.98, indicating both genotoxicity and cytotoxicity of these two metals, while ratios <1.0 postexposure to Cu showed its cytotoxic impacts on ADPWH_recA bioreporter. Metal mixtures exhibited enhanced antagonistic effects (Ti > 4.0) determined by the Toxic Unit model. With 100 mg/L alkane, the morbidity of ADPWH-recA reduced to <20%, showing the inhibition of alkanes on Cd toxicity. Exposed to the metal mixture containing 10 mg/L Cu, the weak binding affinity of Cu with alkanes contributed to a high morbidity of > 85% in ADPWH_recA cells. This study provides a new way to understand the toxicity of mixture contaminants, which can help to optimize treatment efficiencies of bacterial remediation for oil contamination. ",
keywords = "Bioavailability, Biosensor, Mixture toxicity, Toxic unit model, Bacteria, Binding energy, Biochemistry, Biodegradation, Bioremediation, Biosensors, Biotechnology, Cytotoxicity, Diseases, Heavy metals, Paraffins, Soil pollution, Acinetobacters, Contaminated water, Degrading bacteria, Hydrocarbons mixtures, Metal mixtures, Oil contaminated soil, Oil spillage, Soil and water, Mixtures, Acinetobacter baylyi, Bacteria (microorganisms)",
author = "H. Li and Y. Yang and D. Zhang and Y. Li and H. Zhang and J. Luo and K.C. Jones",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Journal of Hazardous Materials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Hazardous Materials, 419, 2021 DOI: 10.1016/j.jhazmat.2021.126471",
year = "2021",
month = oct,
day = "5",
doi = "10.1016/j.jhazmat.2021.126471",
language = "English",
volume = "419",
journal = "Journal of Hazardous Materials",
issn = "0304-3894",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Evaluating the simulated toxicities of metal mixtures and hydrocarbons using the alkane degrading bioreporter Acinetobacter baylyi ADPWH_recA

AU - Li, H.

AU - Yang, Y.

AU - Zhang, D.

AU - Li, Y.

AU - Zhang, H.

AU - Luo, J.

AU - Jones, K.C.

N1 - This is the author’s version of a work that was accepted for publication in Journal of Hazardous Materials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Hazardous Materials, 419, 2021 DOI: 10.1016/j.jhazmat.2021.126471

PY - 2021/10/5

Y1 - 2021/10/5

N2 - Oil spillages lead to the formation of hydrocarbon and metal mixtures possessing effects on alkane-degrading bacteria that are responsible for the bioremediation of oil-contaminated soils and waters. Studies of bacterial responses to the mixture of petroleum and metal can inform appropriate strategies for bioremediation. We employed a luminescent bioreporter Acinetobacter baylyi ADPWH_recA with alkane degradation capability to evaluate the combined effects from heavy metals (Cd, Pb and Cu) and alkanes (dodecane, tetradecane, hexadecane and octadecane). Bioluminescent ratios of ADPWH_recA in single Cd or Pb treatments ranged from 0.25 to 1.98, indicating both genotoxicity and cytotoxicity of these two metals, while ratios <1.0 postexposure to Cu showed its cytotoxic impacts on ADPWH_recA bioreporter. Metal mixtures exhibited enhanced antagonistic effects (Ti > 4.0) determined by the Toxic Unit model. With 100 mg/L alkane, the morbidity of ADPWH-recA reduced to <20%, showing the inhibition of alkanes on Cd toxicity. Exposed to the metal mixture containing 10 mg/L Cu, the weak binding affinity of Cu with alkanes contributed to a high morbidity of > 85% in ADPWH_recA cells. This study provides a new way to understand the toxicity of mixture contaminants, which can help to optimize treatment efficiencies of bacterial remediation for oil contamination. 

AB - Oil spillages lead to the formation of hydrocarbon and metal mixtures possessing effects on alkane-degrading bacteria that are responsible for the bioremediation of oil-contaminated soils and waters. Studies of bacterial responses to the mixture of petroleum and metal can inform appropriate strategies for bioremediation. We employed a luminescent bioreporter Acinetobacter baylyi ADPWH_recA with alkane degradation capability to evaluate the combined effects from heavy metals (Cd, Pb and Cu) and alkanes (dodecane, tetradecane, hexadecane and octadecane). Bioluminescent ratios of ADPWH_recA in single Cd or Pb treatments ranged from 0.25 to 1.98, indicating both genotoxicity and cytotoxicity of these two metals, while ratios <1.0 postexposure to Cu showed its cytotoxic impacts on ADPWH_recA bioreporter. Metal mixtures exhibited enhanced antagonistic effects (Ti > 4.0) determined by the Toxic Unit model. With 100 mg/L alkane, the morbidity of ADPWH-recA reduced to <20%, showing the inhibition of alkanes on Cd toxicity. Exposed to the metal mixture containing 10 mg/L Cu, the weak binding affinity of Cu with alkanes contributed to a high morbidity of > 85% in ADPWH_recA cells. This study provides a new way to understand the toxicity of mixture contaminants, which can help to optimize treatment efficiencies of bacterial remediation for oil contamination. 

KW - Bioavailability

KW - Biosensor

KW - Mixture toxicity

KW - Toxic unit model

KW - Bacteria

KW - Binding energy

KW - Biochemistry

KW - Biodegradation

KW - Bioremediation

KW - Biosensors

KW - Biotechnology

KW - Cytotoxicity

KW - Diseases

KW - Heavy metals

KW - Paraffins

KW - Soil pollution

KW - Acinetobacters

KW - Contaminated water

KW - Degrading bacteria

KW - Hydrocarbons mixtures

KW - Metal mixtures

KW - Oil contaminated soil

KW - Oil spillage

KW - Soil and water

KW - Mixtures

KW - Acinetobacter baylyi

KW - Bacteria (microorganisms)

U2 - 10.1016/j.jhazmat.2021.126471

DO - 10.1016/j.jhazmat.2021.126471

M3 - Journal article

VL - 419

JO - Journal of Hazardous Materials

JF - Journal of Hazardous Materials

SN - 0304-3894

M1 - 126471

ER -