This paper presents a comprehensive analysis of the hydrodynamic forces and moments relating to the drag on an open-frame work-class remotely operated vehicle (ROV) AUTO-1000. We describe the results of planar motion mechanism experiments conducted with the aim of modeling and simplifying the mathematical maneuverability model for such an ROV. The scale of the model is 1:4. Various experiments are performed in a nonlinear wave channel. The flow speeds in the static drag tests range from ±0.2–±0.5 m/s and the angle in the drift tests is less than 10°. The motion frequencies of the dynamic tests range from 0.25 to 3.14 rad/s. The amplitude of the translation motions is 0.03 m and the largest angular amplitude in the rolling tests is 5°. The viscous and inertial hydrodynamic coefficients are estimated. Normalized sensitivity coefficients are used to investigate the sensitivity of both the viscous and inertial hydrodynamic coefficients considering the multi-degree-of-freedom motion and velocity effect. The drag, drift, and stationary random motions are used to examine the sensitivity. A comparison of the motion simulation results given by simplified and complete models shows that a threshold normalized sensitivity coefficient value of 0.01 is suitable for filtering the ROV coefficients.