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Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite

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Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. / Huang, J.; Di Silvio, L.; Wang, M.; Rehman, I.; Ohtsuki, C.; Bonfield, W.

In: Journal of Materials Science: Materials in Medicine, Vol. 8, No. 12, 1997, p. 809-813.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Huang, J, Di Silvio, L, Wang, M, Rehman, I, Ohtsuki, C & Bonfield, W 1997, 'Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite', Journal of Materials Science: Materials in Medicine, vol. 8, no. 12, pp. 809-813. https://doi.org/10.1023/A:1018581100400

APA

Huang, J., Di Silvio, L., Wang, M., Rehman, I., Ohtsuki, C., & Bonfield, W. (1997). Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. Journal of Materials Science: Materials in Medicine, 8(12), 809-813. https://doi.org/10.1023/A:1018581100400

Vancouver

Huang J, Di Silvio L, Wang M, Rehman I, Ohtsuki C, Bonfield W. Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. Journal of Materials Science: Materials in Medicine. 1997;8(12):809-813. https://doi.org/10.1023/A:1018581100400

Author

Huang, J. ; Di Silvio, L. ; Wang, M. ; Rehman, I. ; Ohtsuki, C. ; Bonfield, W. / Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. In: Journal of Materials Science: Materials in Medicine. 1997 ; Vol. 8, No. 12. pp. 809-813.

Bibtex

@article{dadc0ef0b47b4d89bfc55adf79474667,
title = "Evaluation of in vitro bioactivity and biocompatibility of Bioglass{\textregistered}-reinforced polyethylene composite",
abstract = "The bioactivity and biocompatibility of Bioglass{\textregistered}-reinforced high-density polyethylene composite (Bioglass{\textregistered}/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass{\textregistered}/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass{\textregistered}/HDPE composites have a promising biological response as a potential implant material. The bioactivity and biocompatibility of Bioglass-reinforced high-density polyethylene composite (Bioglass/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass/HDPE composites have a promising biological response as a potential implant material.",
keywords = "Biocompatibility, Glass, High density polyethylenes, Infrared spectroscopy, Metabolism, Nonmetallic matrix composites, Reinforced plastics, Scanning electron microscopy, Tissue culture, X ray diffraction analysis, Bioactivity, Bioglass, Implants (surgical), apatite, biomaterial, glass, polyethylene, biocompatibility, cell culture, conference paper, drug activity, human, human cell, implant, infrared spectroscopy, osteoblast, priority journal, scanning electron microscopy, X ray diffraction",
author = "J. Huang and {Di Silvio}, L. and M. Wang and I. Rehman and C. Ohtsuki and W. Bonfield",
year = "1997",
doi = "10.1023/A:1018581100400",
language = "English",
volume = "8",
pages = "809--813",
journal = "Journal of Materials Science: Materials in Medicine",
issn = "0957-4530",
publisher = "Kluwer Academic Publishers",
number = "12",

}

RIS

TY - JOUR

T1 - Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite

AU - Huang, J.

AU - Di Silvio, L.

AU - Wang, M.

AU - Rehman, I.

AU - Ohtsuki, C.

AU - Bonfield, W.

PY - 1997

Y1 - 1997

N2 - The bioactivity and biocompatibility of Bioglass®-reinforced high-density polyethylene composite (Bioglass®/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass®/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass®/HDPE composites have a promising biological response as a potential implant material. The bioactivity and biocompatibility of Bioglass-reinforced high-density polyethylene composite (Bioglass/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass/HDPE composites have a promising biological response as a potential implant material.

AB - The bioactivity and biocompatibility of Bioglass®-reinforced high-density polyethylene composite (Bioglass®/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass®/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass®/HDPE composites have a promising biological response as a potential implant material. The bioactivity and biocompatibility of Bioglass-reinforced high-density polyethylene composite (Bioglass/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass/HDPE composites have a promising biological response as a potential implant material.

KW - Biocompatibility

KW - Glass

KW - High density polyethylenes

KW - Infrared spectroscopy

KW - Metabolism

KW - Nonmetallic matrix composites

KW - Reinforced plastics

KW - Scanning electron microscopy

KW - Tissue culture

KW - X ray diffraction analysis

KW - Bioactivity

KW - Bioglass

KW - Implants (surgical)

KW - apatite

KW - biomaterial

KW - glass

KW - polyethylene

KW - biocompatibility

KW - cell culture

KW - conference paper

KW - drug activity

KW - human

KW - human cell

KW - implant

KW - infrared spectroscopy

KW - osteoblast

KW - priority journal

KW - scanning electron microscopy

KW - X ray diffraction

U2 - 10.1023/A:1018581100400

DO - 10.1023/A:1018581100400

M3 - Journal article

VL - 8

SP - 809

EP - 813

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 12

ER -