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Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells

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Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells. / OWEN, P J ; MARRIOTT, D B ; BOARDER, M R .
In: British Journal of Pharmacology, Vol. 97, No. 1, 05.1989, p. 133-138.

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OWEN PJ, MARRIOTT DB, BOARDER MR. Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells. British Journal of Pharmacology. 1989 May;97(1):133-138. doi: 10.1111/j.1476-5381.1989.tb11933.x

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OWEN, P J ; MARRIOTT, D B ; BOARDER, M R . / Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells. In: British Journal of Pharmacology. 1989 ; Vol. 97, No. 1. pp. 133-138.

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@article{e013f1f251aa4ec08886f6fa68700aa6,
title = "Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells",
abstract = "1It has been suggested that neuronal voltage-sensitive calcium channels (VSCC) may be divided into dihydropyridine (DHP)-sensitive (L) and DHP-insensitive (N and T), and that both the L and the N type channels are attenuated by the peptide blocker ω-conotoxin. Here the effects of ω-conotoxin on release of noradrenaline and uptake of calcium in bovine adrenal chromaffin cells were investigated.2Release of noradrenaline in response to 25 mm K+, 65 mm K+, 10 nm bradykinin or 10 μm prostaglandin E1 was not affected by ω-conotoxin in the range 10 nm-1 μm.345Ca2+ uptake stimulated by high K+ and prostaglandin was attenuated by 1 μm nitrendipine and enhanced by 1 μm Bay K 8644; these calcium fluxes were not modified by 20 nm ω-conotoxin.4With superfused rat brain striatal slices in the same medium as the above cell studies, release of dopamine in response to 25 mm K+ was attenuated by 20 nm ω-conotoxin.5These results show that in these neurone-like cells, release may be effected by calcium influx through DHP-sensitive but ω-conotoxin-insensitive VSCC, a result inconsistent with the suggestion that ω-conotoxin blocks both L-type and N-type neuronal calcium channels.",
author = "OWEN, {P J} and MARRIOTT, {D B} and BOARDER, {M R}",
year = "1989",
month = may,
doi = "10.1111/j.1476-5381.1989.tb11933.x",
language = "English",
volume = "97",
pages = "133--138",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells

AU - OWEN, P J

AU - MARRIOTT, D B

AU - BOARDER, M R

PY - 1989/5

Y1 - 1989/5

N2 - 1It has been suggested that neuronal voltage-sensitive calcium channels (VSCC) may be divided into dihydropyridine (DHP)-sensitive (L) and DHP-insensitive (N and T), and that both the L and the N type channels are attenuated by the peptide blocker ω-conotoxin. Here the effects of ω-conotoxin on release of noradrenaline and uptake of calcium in bovine adrenal chromaffin cells were investigated.2Release of noradrenaline in response to 25 mm K+, 65 mm K+, 10 nm bradykinin or 10 μm prostaglandin E1 was not affected by ω-conotoxin in the range 10 nm-1 μm.345Ca2+ uptake stimulated by high K+ and prostaglandin was attenuated by 1 μm nitrendipine and enhanced by 1 μm Bay K 8644; these calcium fluxes were not modified by 20 nm ω-conotoxin.4With superfused rat brain striatal slices in the same medium as the above cell studies, release of dopamine in response to 25 mm K+ was attenuated by 20 nm ω-conotoxin.5These results show that in these neurone-like cells, release may be effected by calcium influx through DHP-sensitive but ω-conotoxin-insensitive VSCC, a result inconsistent with the suggestion that ω-conotoxin blocks both L-type and N-type neuronal calcium channels.

AB - 1It has been suggested that neuronal voltage-sensitive calcium channels (VSCC) may be divided into dihydropyridine (DHP)-sensitive (L) and DHP-insensitive (N and T), and that both the L and the N type channels are attenuated by the peptide blocker ω-conotoxin. Here the effects of ω-conotoxin on release of noradrenaline and uptake of calcium in bovine adrenal chromaffin cells were investigated.2Release of noradrenaline in response to 25 mm K+, 65 mm K+, 10 nm bradykinin or 10 μm prostaglandin E1 was not affected by ω-conotoxin in the range 10 nm-1 μm.345Ca2+ uptake stimulated by high K+ and prostaglandin was attenuated by 1 μm nitrendipine and enhanced by 1 μm Bay K 8644; these calcium fluxes were not modified by 20 nm ω-conotoxin.4With superfused rat brain striatal slices in the same medium as the above cell studies, release of dopamine in response to 25 mm K+ was attenuated by 20 nm ω-conotoxin.5These results show that in these neurone-like cells, release may be effected by calcium influx through DHP-sensitive but ω-conotoxin-insensitive VSCC, a result inconsistent with the suggestion that ω-conotoxin blocks both L-type and N-type neuronal calcium channels.

U2 - 10.1111/j.1476-5381.1989.tb11933.x

DO - 10.1111/j.1476-5381.1989.tb11933.x

M3 - Journal article

VL - 97

SP - 133

EP - 138

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 1

ER -