Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Evidence for the occurrence of myotonia in the extraocular musculature in patients with dystrophia myotonica
AU - Hansen, H. C.
AU - Lueck, C. J.
AU - Crawford, T. J.
AU - Kennard, C.
AU - Zangemeister, W. H.
PY - 1993
Y1 - 1993
N2 - Dystrophia myotonica (DM) is a multisystem disorder which has been reported to affect eye movements. There is, however, disagreement in the literature as to whether the observed slowing of saccadic eye movements is due to a central abnormality or due to abnormalities of the extraocular muscles themselves. A ‘warm-up’ effect is well known to occur in the peripheral muscles in DM. This effect involves a progressive decrease in the degree of myotonia observed with each successive relaxation during a period of repetitive contraction and relaxation of a given muscle. The authors have studied seven patients using two different paradigms to provide evidence that the ‘warm-up’ phenomenon can be demonstrated in extraocular musculature in patients with DM. Such an effect is not seen in controls. The observation of a ‘warm-up’ phenomenon suggests that the disorder of saccadic eye movements is likely to be due to an abnormality of the extraocular muscles themselves rather than a central mechanism.
AB - Dystrophia myotonica (DM) is a multisystem disorder which has been reported to affect eye movements. There is, however, disagreement in the literature as to whether the observed slowing of saccadic eye movements is due to a central abnormality or due to abnormalities of the extraocular muscles themselves. A ‘warm-up’ effect is well known to occur in the peripheral muscles in DM. This effect involves a progressive decrease in the degree of myotonia observed with each successive relaxation during a period of repetitive contraction and relaxation of a given muscle. The authors have studied seven patients using two different paradigms to provide evidence that the ‘warm-up’ phenomenon can be demonstrated in extraocular musculature in patients with DM. Such an effect is not seen in controls. The observation of a ‘warm-up’ phenomenon suggests that the disorder of saccadic eye movements is likely to be due to an abnormality of the extraocular muscles themselves rather than a central mechanism.
KW - dystrophia myotonica
KW - saccades
KW - peak velocity
KW - ‘warm-up’ phenomenon
U2 - 10.3109/01658109309036998
DO - 10.3109/01658109309036998
M3 - Journal article
VL - 13
SP - 17
EP - 24
JO - Neuro-Ophthalmology
JF - Neuro-Ophthalmology
IS - 1
ER -