Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Expression of TGF-beta isoforms during first trimester human embryogenesis
AU - Gatherer, D.
AU - Ten Dijke, P.
AU - Baird, D. T.
AU - Akhurst, R. J.
PY - 1990/10
Y1 - 1990/10
N2 - We have studied the expression of the genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 in human embryos ranging from 32 to 57 days post-coitum, using in situ hybridization. The spatial and temporal pattern of expression of each gene is distinct, though each occasionally overlaps. TGF-beta 1 is expressed in haematopoietic, endothelial and osteogenic tissues. TGF-beta 2 and TGF-beta 3 are expressed in a wide variety of mesenchymal tissues including areas of chondrogenic activity. TGF-beta 2 is also found in several epithelial and in the ventral nervous system. The differential transcript distributions are broadly similar to those seen in mouse embryos suggesting that there is conservation of TGF-beta gene regulatory sequences and developmental function across this species boundary.
AB - We have studied the expression of the genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 in human embryos ranging from 32 to 57 days post-coitum, using in situ hybridization. The spatial and temporal pattern of expression of each gene is distinct, though each occasionally overlaps. TGF-beta 1 is expressed in haematopoietic, endothelial and osteogenic tissues. TGF-beta 2 and TGF-beta 3 are expressed in a wide variety of mesenchymal tissues including areas of chondrogenic activity. TGF-beta 2 is also found in several epithelial and in the ventral nervous system. The differential transcript distributions are broadly similar to those seen in mouse embryos suggesting that there is conservation of TGF-beta gene regulatory sequences and developmental function across this species boundary.
KW - Bone and Bones
KW - Cardiovascular System
KW - Embryo, Mammalian
KW - Humans
KW - Isomerism
KW - Liver
KW - Lung
KW - Morphogenesis
KW - Nervous System
KW - Nucleic Acid Hybridization
KW - Transforming Growth Factor beta
M3 - Journal article
C2 - 2133548
VL - 110
SP - 445
EP - 460
JO - Development
JF - Development
SN - 0950-1991
IS - 2
ER -