Expression of TGF-beta isoforms during first trimester human embryogenesis

Biomedical and Life Sciences

Keywords

Bone and Bones, Cardiovascular System, Embryo, Mammalian, Humans, Isomerism, Liver, Lung, Morphogenesis, Nervous System, Nucleic Acid Hybridization, Transforming Growth Factor beta

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Expression of TGF-beta isoforms during first trimester human embryogenesis. / Gatherer, D.; Ten Dijke, P.; Baird, D. T. et al.
In: Development, Vol. 110, No. 2, 10.1990, p. 445-460.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Author

Gatherer, D. ; Ten Dijke, P. ; Baird, D. T. et al. / Expression of TGF-beta isoforms during first trimester human embryogenesis. In: Development. 1990 ; Vol. 110, No. 2. pp. 445-460.

Bibtex

@article{1e3627be687c43f48ba7f9417156a75c,

title = "Expression of TGF-beta isoforms during first trimester human embryogenesis",

abstract = "We have studied the expression of the genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 in human embryos ranging from 32 to 57 days post-coitum, using in situ hybridization. The spatial and temporal pattern of expression of each gene is distinct, though each occasionally overlaps. TGF-beta 1 is expressed in haematopoietic, endothelial and osteogenic tissues. TGF-beta 2 and TGF-beta 3 are expressed in a wide variety of mesenchymal tissues including areas of chondrogenic activity. TGF-beta 2 is also found in several epithelial and in the ventral nervous system. The differential transcript distributions are broadly similar to those seen in mouse embryos suggesting that there is conservation of TGF-beta gene regulatory sequences and developmental function across this species boundary.",

keywords = "Bone and Bones, Cardiovascular System, Embryo, Mammalian, Humans, Isomerism, Liver, Lung, Morphogenesis, Nervous System, Nucleic Acid Hybridization, Transforming Growth Factor beta",

author = "D. Gatherer and {Ten Dijke}, P. and Baird, {D. T.} and Akhurst, {R. J.}",

year = "1990",

month = oct,

language = "English",

volume = "110",

pages = "445--460",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "2",

}

RIS

TY - JOUR

T1 - Expression of TGF-beta isoforms during first trimester human embryogenesis

AU - Gatherer, D.

AU - Ten Dijke, P.

AU - Baird, D. T.

AU - Akhurst, R. J.

PY - 1990/10

Y1 - 1990/10

N2 - We have studied the expression of the genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 in human embryos ranging from 32 to 57 days post-coitum, using in situ hybridization. The spatial and temporal pattern of expression of each gene is distinct, though each occasionally overlaps. TGF-beta 1 is expressed in haematopoietic, endothelial and osteogenic tissues. TGF-beta 2 and TGF-beta 3 are expressed in a wide variety of mesenchymal tissues including areas of chondrogenic activity. TGF-beta 2 is also found in several epithelial and in the ventral nervous system. The differential transcript distributions are broadly similar to those seen in mouse embryos suggesting that there is conservation of TGF-beta gene regulatory sequences and developmental function across this species boundary.

AB - We have studied the expression of the genes encoding transforming growth factors (TGFs) beta 1, beta 2 and beta 3 in human embryos ranging from 32 to 57 days post-coitum, using in situ hybridization. The spatial and temporal pattern of expression of each gene is distinct, though each occasionally overlaps. TGF-beta 1 is expressed in haematopoietic, endothelial and osteogenic tissues. TGF-beta 2 and TGF-beta 3 are expressed in a wide variety of mesenchymal tissues including areas of chondrogenic activity. TGF-beta 2 is also found in several epithelial and in the ventral nervous system. The differential transcript distributions are broadly similar to those seen in mouse embryos suggesting that there is conservation of TGF-beta gene regulatory sequences and developmental function across this species boundary.

KW - Bone and Bones

KW - Cardiovascular System

KW - Embryo, Mammalian

KW - Humans

KW - Isomerism

KW - Liver

KW - Lung

KW - Morphogenesis

KW - Nervous System

KW - Nucleic Acid Hybridization

KW - Transforming Growth Factor beta

M3 - Journal article

C2 - 2133548

VL - 110

SP - 445

EP - 460

JO - Development

JF - Development

SN - 0950-1991

IS - 2

ER -

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