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  • Krzystanek2016Revised

    Rights statement: This is the author’s version of a work that was accepted for publication in Pharmacological Reports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacological Reports, 68, 5, 2016 DOI: 10.1016/j.pharep.2016.05.009

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Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon

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Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. / Krzystanek, Marek; Bogus, Katarzyna; Palasz, Artur; Wiaderkiewicz, Anna; Filipczyk, Lukasz; Rojczyk, Ewa; Worthington, John Joseph; Wiaderkiewicz, Ryszard.

In: Pharmacological reports : PR, Vol. 68, No. 5, 10.2016, p. 990-995.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Krzystanek, M, Bogus, K, Palasz, A, Wiaderkiewicz, A, Filipczyk, L, Rojczyk, E, Worthington, JJ & Wiaderkiewicz, R 2016, 'Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon', Pharmacological reports : PR, vol. 68, no. 5, pp. 990-995. https://doi.org/10.1016/j.pharep.2016.05.009

APA

Krzystanek, M., Bogus, K., Palasz, A., Wiaderkiewicz, A., Filipczyk, L., Rojczyk, E., Worthington, J. J., & Wiaderkiewicz, R. (2016). Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. Pharmacological reports : PR, 68(5), 990-995. https://doi.org/10.1016/j.pharep.2016.05.009

Vancouver

Krzystanek M, Bogus K, Palasz A, Wiaderkiewicz A, Filipczyk L, Rojczyk E et al. Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. Pharmacological reports : PR. 2016 Oct;68(5):990-995. https://doi.org/10.1016/j.pharep.2016.05.009

Author

Krzystanek, Marek ; Bogus, Katarzyna ; Palasz, Artur ; Wiaderkiewicz, Anna ; Filipczyk, Lukasz ; Rojczyk, Ewa ; Worthington, John Joseph ; Wiaderkiewicz, Ryszard. / Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. In: Pharmacological reports : PR. 2016 ; Vol. 68, No. 5. pp. 990-995.

Bibtex

@article{627aef635483466590cce5db366f175c,
title = "Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon",
abstract = "BackgroundThis study aimed to evaluate the effect of extended olanzapine, clozapine and haloperidol administration on NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.MethodsTo explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was performed.ResultsInterestingly, all neuroleptics caused a downregulation of NMDA-R subunit expression in the thalamus but increased the level of NR1 in the hypothalamus. Olanzapine upregulated hypothalamic NR2A expression, while clozapine and haloperidol decreased hypothalamic levels. We observed no significant changes in NR2B immunoreactivity. None of the studied medications had significant influence on NMDA-R subunit expression in the neocortex.ConclusionsNeuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico–striato–thalamo–cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances.",
keywords = "NMDA receptor, neuroleptics, glutamate, neocortex, diencephalon",
author = "Marek Krzystanek and Katarzyna Bogus and Artur Palasz and Anna Wiaderkiewicz and Lukasz Filipczyk and Ewa Rojczyk and Worthington, {John Joseph} and Ryszard Wiaderkiewicz",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Pharmacological Reports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacological Reports, 68, 5, 2016 DOI: 10.1016/j.pharep.2016.05.009",
year = "2016",
month = oct,
doi = "10.1016/j.pharep.2016.05.009",
language = "English",
volume = "68",
pages = "990--995",
journal = "Pharmacological reports : PR",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "5",

}

RIS

TY - JOUR

T1 - Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon

AU - Krzystanek, Marek

AU - Bogus, Katarzyna

AU - Palasz, Artur

AU - Wiaderkiewicz, Anna

AU - Filipczyk, Lukasz

AU - Rojczyk, Ewa

AU - Worthington, John Joseph

AU - Wiaderkiewicz, Ryszard

N1 - This is the author’s version of a work that was accepted for publication in Pharmacological Reports. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacological Reports, 68, 5, 2016 DOI: 10.1016/j.pharep.2016.05.009

PY - 2016/10

Y1 - 2016/10

N2 - BackgroundThis study aimed to evaluate the effect of extended olanzapine, clozapine and haloperidol administration on NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.MethodsTo explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was performed.ResultsInterestingly, all neuroleptics caused a downregulation of NMDA-R subunit expression in the thalamus but increased the level of NR1 in the hypothalamus. Olanzapine upregulated hypothalamic NR2A expression, while clozapine and haloperidol decreased hypothalamic levels. We observed no significant changes in NR2B immunoreactivity. None of the studied medications had significant influence on NMDA-R subunit expression in the neocortex.ConclusionsNeuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico–striato–thalamo–cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances.

AB - BackgroundThis study aimed to evaluate the effect of extended olanzapine, clozapine and haloperidol administration on NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.MethodsTo explore NR1, NR2A and NR2B subunit protein expression, densytometric analysis of immunohistochemically stained brain slices was performed.ResultsInterestingly, all neuroleptics caused a downregulation of NMDA-R subunit expression in the thalamus but increased the level of NR1 in the hypothalamus. Olanzapine upregulated hypothalamic NR2A expression, while clozapine and haloperidol decreased hypothalamic levels. We observed no significant changes in NR2B immunoreactivity. None of the studied medications had significant influence on NMDA-R subunit expression in the neocortex.ConclusionsNeuroleptic-induced reduction in the expression of thalamic NMDA-R subunits may play an important role in the regulation of glutamatergic transmission disorders in cortico–striato–thalamo–cortical loop in schizophrenia. A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances.

KW - NMDA receptor

KW - neuroleptics

KW - glutamate

KW - neocortex

KW - diencephalon

U2 - 10.1016/j.pharep.2016.05.009

DO - 10.1016/j.pharep.2016.05.009

M3 - Journal article

VL - 68

SP - 990

EP - 995

JO - Pharmacological reports : PR

JF - Pharmacological reports : PR

SN - 1734-1140

IS - 5

ER -